Biological Mother‐To‐Child Living Donor Liver Transplantation: Early Vs. Late Postpartum Donation
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Le résumé fourni par la source
INTRODUCTION: Biological parental donations provide the best option for many pediatric recipients, yielding unique immunological benefits that may enable minimization of immunosuppression in transplanted children. However, living related maternal donation in the postpartum period may introduce an increased risk of donor complications due to the physiological changes of pregnancy and childbirth, and the optimal timing of postpartum living donation is unknown. METHODS: Using US national registry data, we characterized donor and recipient outcomes for pediatric living donor liver transplants performed between 2004 and 2022 where a biological mother donated to a child ≤ 24 months old. RESULTS: Our study population included 256 donor-recipient pairs, with biliary atresia representing the most common indication for transplantation (68.0%). Donors had a median [IQR] age of 30 [25, 34] years, and the median [IQR] time from birth to donation was 9.0 [6.8, 13.0] months. 6.3% of donors experienced a biliary or other complication. When stratifying by donors who donated ≤ 6 vs. > 6 months postpartum, we found no significant differences in donor complications or readmission. Stratified analyses were also comparable for recipient mortality, graft survival, and rejection-free survival. Donors ≤ 6 months postpartum (n = 64) were more likely to experience reoperation than mothers who donated > 6 months postpartum (n = 192) (6.2% vs. 1.0%, p = 0.04). CONCLUSIONS: While maternal living donor liver transplantation is safe for most donors, there is a higher risk of reoperation when donation is performed ≤ 6 months postpartum. Surgeons should be aware that these donors are a higher risk population, requiring discussion upon consent and warranting close post-operative monitoring.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Biological Mother‐To‐Child Living Donor Liver Transplantation: Early Vs. Late Postpartum Donation
- Date Crossref
- 28/08/2026
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Miami Transplant Institute pays non établi dans la noticeÉtablissement de santé
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University of North Carolina at Chapel Hill pays non établi dans la noticeUniversité ou école supérieure
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NYU Langone Health pays non établi dans la noticeÉtablissement de santé
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National Marrow Donor Program pays non établi dans la noticeOrganisation à but non lucratif
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Department of Surgery Transplant Institute pays non établi dans la noticeStructure de recherche
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Department of Obstetrics and Gynecology The University of North Carolina Chapel Hill North Carolina USA Division of Maternal Fetal Medicine pays non établi dans la noticeUniversité ou école supérieure
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Scientific Registry of Transplant Recipients Minneapolis Minnesota USA pays non établi dans la noticeInstitution
Miami Transplant Institute, University of North Carolina at Chapel Hill et NYU Langone Health, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.