Establishment of a chemoradio-resistance colorectal cancer cell model and its changes in biological behavior
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Le résumé fourni par la source
Background: Colorectal cancer (CRC) is the most prevalent and malignant gastrointestinal tract tumor. The incidence remains high, and the issue of resistance to radiotherapy and chemotherapy is prominent. The aims were therefore to establish a model for radio- and chemoresistance in CRC, elucidating the underlying mechanism that could help identify measures to reverse its resistance and improve the clinical efficacy of radiotherapy and chemotherapy. Methods: A HCT116 and HT29 cell model of radiotherapy and chemotherapy resistance in CRC was established by simulating clinical high-dose shock therapy as a key in vitro method. For the in vivo animal studies, healthy 6-week-old BALB/c nude mice (both genders) were used. The changes in its biological behavior were studied to provide a theoretical basis for improving the efficacy of radiotherapy and chemotherapy in clinical practice. Results: We successfully established a CRC cell line with radio- and chemoresistance, and it exhibited stronger potential for cell proliferation, colony formation, invasion, and migration than its parental cell line. Furthermore, in nude mouse models, the resistant cells showed stronger tumorigenicity and stronger liver and lung metastasis ability than the parental cells. Conclusions: This research helps elucidate the molecular mechanism of chemo- and radiotherapy resistance in CRC and can potentially improve the molecular diagnosis and gene therapy of CRC.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Establishment of a chemoradio-resistance colorectal cancer cell model and its changes in biological behavior
- Date Crossref
- 01/08/2026
- Éditeur
- AME Publishing Company
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Kunming Medical University Department of Combination of Traditional Chinese and Western Medicine pays non établi dans la noticeUniversité ou école supérieure
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Punan Hospital pays non établi dans la noticeÉtablissement de santé
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The First Hospital of Kunming pays non établi dans la noticeÉtablissement de santé
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Command Hospital Air Force pays non établi dans la noticeÉtablissement de santé
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Dali Traditional Chinese Medicine Hospital pays non établi dans la noticeÉtablissement de santé
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Xiangyang Hospital of Traditional Chinese Medicine pays non établi dans la noticeÉtablissement de santé
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Puning Overseas Chinese Hospital Department of Internal Medicine pays non établi dans la noticeÉtablissement de santé
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The Third Affiliated Hospital of Kumming Medical University Department of Gynecological Oncology pays non établi dans la noticeUniversité ou école supérieure
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Department of Otolaryngology pays non établi dans la noticeOrganisation à but non lucratif
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PLA Air Force Hospital of the Western Theater Command pays non établi dans la noticeÉtablissement de santé
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Xiangyun County Traditional Chinese Medicine Hospital Department of Pulmonary Diseases pays non établi dans la noticeÉtablissement de santé
Department of Combination of Traditional Chinese and Western Medicine — Kunming Medical University, Punan Hospital et The First Hospital of Kunming, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.