Effects of the DASH4D diet on biomarkers of glycemia in adults with type 2 diabetes: A secondary analysis of the DASH4D randomized clinical trial

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Objective: To examine the effect of the DASH4D diet (a DASH-style diet tailored for diabetes) on biomarkers of glycemia. Research Design and Methods: In this controlled feeding trial, adults with type 2 diabetes were fed four diets in a random order: DASH4D diet or comparison diet (representative of a typical American diet), each with higher or lower sodium. Each feeding period lasted 5 weeks. Using an intention-to-treat approach, we estimated the effect of the DASH4D (versus comparison) diet on fructosamine, fasting glucose, and HbA1c with linear mixed effect models. Results: Among 101 participants (mean age 67 years, 65% female, 87% Black adults), compared to the comparison diet, the DASH4D diet significantly reduced end-of-period fructosamine (adjusted difference: -5.6 μmol/L, P=0.002), fasting glucose (adjusted difference: -4.5 mg/dL; P=0.02) and HbA1c (adjusted difference: -0.09%-points; P=0.04). Conclusion: Our results support recommending the DASH4D diet for glycemic management in type 2 diabetes.

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