Additional file 1 of HSPA8 orchestrates SNARE complex assembly to drive extracellular vesicle-mediated spread of p-tau217 in Alzheimer's disease

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Additional file 1. Figure S1. The levels of free-form p-tau217 in human CSF and plasma. Figure S2. The efflux of p-tau217+ EVs across the BBB in AD. Figure S3. Characterization of EVs. Figure S4. The levels of other multiple p-tau and their EVs in Aβ-treated cells. Figure S5. HSPA8 knockdown efficiency confirmed by WB. Figure S6. The interactions between SNAP23, SNAP29, and t-tau in vitro. Figure S7. The interactions between SNAP23, SNAP29, HSPA8, and Aβ in CA4 and DG. Figure S8. Effects of 25-mer treatment on Aβ pathology and tau phosphorylation in APP/PS1 mice. Figure S9. Uncropped Western Blot images related to Figure 2. Figure S10. Uncropped Western Blot images related to Figure 3. Figure S11. Uncropped Western Blot images related to Figure 4. Figure S12. Uncropped Western Blot images related to Figure 7. Figure S13. Uncropped Western Blot images related to Figure S3. Figure S14. Uncropped Western Blot images related to Figure S5. Table S1. Characteristics of the human CSF and plasma samples. Table S2. List of primer sequences. Table S3. List of primary antibodies. Table S4. Top 15 Hub Genes.

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