Early epidemiologic and genomic insights from Sierra Leone's first mpox cases, 2025.

Le résumé fourni par la source

Introduction: March 2025) to generate epidemiologic and genomic intelligence for response. Methods: we summarized surveillance data and sequenced 18 early cases with Oxford Nanopore. Firth-penalized logistic regression was employed to explore risk factors for severe disease. Results: =0.31; date randomization p= 0.18), so we did not interpret clock estimates. Conclusion: real-time analysis during the initial outbreak phase showed community transmission, quantified household spread, documented two sub-lineages with an APOBEC3 signature, and generated severity hypotheses that immediately informed surveillance and vaccine prioritization. Findings require validation in larger cohorts.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.