Gender differences in adiponectin levels among obese individuals and their association with cardiovascular disease
Rattachement africain : cn. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Obesity is one of the major risk factors for cardiovascular disease Adiponectin, an adipokine with cardioprotective effects, exhibits significant sex differences, with higher plasma levels observed in women. However, the mechanistic basis of this sex difference and its pathophysiological significance in obesity-related cardiovascular disease require further elucidation. This review systematically examines the gender-specific pathways ranging from gonadotropins to adiponectin expression and signalling, as well as how dysregulation of these pathways in the context of obesity leads to cardiac damage. We propose that dysfunction of epicardial adipose tissue acts as a key hub, with local inflammation and alterations in adipokine signalling exacerbating coronary atherosclerosis, myocardial fibrosis and arrhythmias. Furthermore, we have examined the clinical conundrum known as the adiponectin paradox in advanced cardiometabolic diseases. In summary, a deeper understanding of the gender dimorphism of adiponectin is crucial for recognising gender-specific susceptibilities and may provide a strategic basis for future approaches to addressing obesity-mediated cardiovascular complications.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Gender differences in adiponectin levels among obese individuals and their association with cardiovascular disease
- Date Crossref
- 27/08/2026
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Second Hospital of Shandong University pays non établi dans la noticeÉtablissement de santé
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Second Affiliated Hospital of Shandong University of TCM pays non établi dans la noticeÉtablissement de santé
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Affiliated Hospital of Shandong Second Medical University Department of General Medicine pays non établi dans la noticeUniversité ou école supérieure
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School of Clinical Medicine pays non établi dans la noticeUniversité ou école supérieure
Second Hospital of Shandong University, Second Affiliated Hospital of Shandong University of TCM et Department of General Medicine — Affiliated Hospital of Shandong Second Medical University, avec 1 autre affiliation.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.