Impaired acute metabolic responses to submaximal exercise in peripheral artery disease (PAD)
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Le résumé fourni par la source
Background: Peripheral artery disease (PAD) is a prevalent manifestation of systemic atherosclerosis and is associated with substantial morbidity, impaired functional capacity, and adverse cardiovascular outcomes. Although reduced walking performance is a defining clinical feature of PAD, the underlying biological responses to acute physiological stress remain poorly understood. Methods: We conducted a prospective observational study including 35 patients with PAD and 36 control participants. All participants’ serum samples were collected immediately before exercise and 5 minutes after exercise. Acute metabolic responses were quantified using targeted liquid chromatography-tandem mass spectrometry. Functional assessments, between-group comparisons, and associations with disease severity were evaluated using nonparametric methods. Results: Compared with control participants, patients with PAD exhibited distinct alterations in exercise-induced metabolic responses. Hypoxanthine showed a robust postexercise increase in controls but a blunted and directionally opposite response in PAD ( p < 0.001), whereas 2-oxoglutarate increased significantly following exercise in PAD but not in controls ( p < 0.001). In exploratory analyses within the PAD group, exercise-induced changes in hypoxanthine and 2-oxoglutarate were not significantly correlated with ankle-brachial index (ABI) or 6-minute walk distance (6MWD) in the available cases. Conclusions: PAD is associated with impaired metabolic flexibility during acute exercise, characterized by altered purine- and tricarboxylic acid-related metabolic responses to exercise, supporting the concept that acute metabolic responses provide clinically relevant information beyond resting assessments in PAD.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Impaired acute metabolic responses to submaximal exercise in peripheral artery disease (PAD)
- Date Crossref
- 27/08/2026
- Éditeur
- SAGE Publications
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Ningxia Medical University Department of Vascular Surgery pays non établi dans la noticeUniversité ou école supérieure
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Ningxia Medical University General Hospital pays non établi dans la noticeÉtablissement de santé
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Guangdong Pharmaceutical University pays non établi dans la noticeUniversité ou école supérieure
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University of Rochester Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Guangzhou Medical University pays non établi dans la noticeUniversité ou école supérieure
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Yecheng County People’s Hospital Department of Ultrasound Medicine pays non établi dans la noticeÉtablissement de santé
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School of Pharmaceutical Sciences Guangdong Provincial Key Laboratory of Molecular Target & pays non établi dans la noticeUniversité ou école supérieure
Department of Vascular Surgery — Ningxia Medical University, Ningxia Medical University General Hospital et Guangdong Pharmaceutical University, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.