Accès ouvert déclaré
2026
article
Joint associations of LDL-C and HDL-C with in-hospital major bleeding in Chinese patients with acute coronary syndrome undergoing PCI: findings from the CCC-ACS project
Wenjun Zhu, Tianqi Yang, Linjie Li, Jingbo Yang, Pengfei Sun, Chuanyi Huang, Geru Aa, Hangkuan Liu, B Sun, L. Liu, Shuting Liu, Qing Yang, Xin Zhou, the CCC-ACS Investigators, Aihua Li, Bao Li, Biao Xu, Guangshu Han, Бин Ли, Bin Liu, Bin Wang, Bing Fu, Bo Yu, Bosong Yang, Caidong Luo, Changqian Wang, Changyong Liu, Chuanliang Liang, Chuanyu Gao, Chunlin Lai, Chuntong Wang, Chunyan Zhang, Chunyang Wu, Congliang Zhang, Cui Bin, Lan Huang, Daoquan Peng, Dawen Xu, Di Wu, Dongmei Zhu, Dongsheng Chai, Dongyan Li, Fakuan Tang, Jun Xiao, Fang Zhao, Fangfang Huang, Fanju Meng, Fengwei Li, Fudong Gan, Gang Xu, Gengsheng Sang, Genshan Ma, Guixia Zhang, Guizhou Tao, Guo Li, Guoduo Chen, Guoqin Xin, Guoqing Li, Guosheng Fu, Guoxiong Chen, Hailong Lin, Haiping Guo, Haiyun Lin, Hong Jiang, Hong Liu, Hong Luan, Hong Zhang, Honghua Deng, Hongwei Li, Honhju Wang, Hualing Liu, Hui Dong, Hui Liu, Huifang Zhang, Huifeng Wang, Huimin Chu, Jiabin Xi, Jian Yang, Jianfeng Ye, Jianhao Li, Jianhong Tao, Jianwen Liu, JiaoMei Yang, Jiawang Ding, Jiayi Tong, Jie Chen, Jie Jiang, Jie Yang, Jifu Li, Jinchuan Yan, Jing Hu, Jing Xu, Jingfeng Wang, Jinglan Diao, Jingshan Zhao, Jinru Wei, Jinxing Yi, Jinzi Su, Jiong Tang, Jiyan Chen, Jiyan Yin, Juexin Fan, Jun Guan, Junbo Ge, Junming Liu, Junping Deng, Junping Fang, Junxia Li, Kaihong Chen, Kalan Luo, Keng Wu, Lang Ji, Lang Li, Li Jiang, Li Wei, Lijun Meng, Likun Ma, Lilong Tang, Lin Wang, Lin Wei, Ling Li, Ling Tao, Liqiong Yang, Lirong Wu, Man Zhang, Kaiming Chen, Meisheng Lai, Miao Tian, Mingcheng Bai, Minghua Han, 陈莫水, Naiyi Liang, Nan Jia, Peiying Zhang, Peng Qu, Pengfei Zhang, Ping Chen, Ping Hou, Ping Xie, Ping Zhang, Pingshuan Dong, Qiang Wu, Qiang Xie, Qiaoqing Zhong, Qichun Wang, Qinfeng Su, Rong Chang, Rong Lin, Ruiping Zhao, Shaobin Jia, Shaoping Nie, Shaowu Ye, Shenghu He, Shengyong Chen, Shixin Ma, Shuangbin Li, Shuanli Xin, Shudong Xia, Shuhua Zhang, Shuqiu Qu, Shuren Ma, Siding Wang, Songbai Li, Suxin Luo, Tao Liu, Tao Zhang, Tian Tuo, Tianchang Li, Tianlun Yang, Tianmin Du, Tongguo Wu, Wei Liu, Wei Mao, Wei Tuo, Wei Wang, Weihong Jiang, Weijian Huang, Weijun Liu, Weiqing Fan, Weiting Xu, Wenhua Lin, Xi Su, Xia Chen, Xianan Zhang, Xianghua Fu, Xiangjun Yang, Xianxian Zhao, Xiaochuan Ma, Xiaofei Sun, Xiaojun Wang, Xiaolan Li, Xiaolei Li, Xiaoli Yang, Xiaoping Chen, Xiaoqin Zhang, Xiaoshu Cheng, Xiaowei Peng, Xiaowen Ma, Xiaoyong Qi, Xiaoyun Feng, Ximing Chen, Xin Tang, Xingsheng Tang, Xingsheng Zhao, Xiufeng Chen, Xudong Li, Xue Li, Xuebo Liu, Xuemei Peng, Yaling Han, Yan Wang, Yanbo Niu, Yang Yu, Yang Zheng, Yanli Wang, Yanlie Zheng, Yansong Guo, Yanzong Yang, Yi Huang, Yin Liu, Ying Guo, Yingchao Luo, Yinglu Hao, Yingxian Sun, Yingzhong Lin, Yitong Ma, Yong Li, Yongdong Li, Yonglin Zhang, Yuanzhe Jin, Yue Li, Yuehua Huang, Yuemin Sun, Yuheng Yang, Yuhua Zhu, Yuhuan Shi, Yulan Zhao, Yuqing Hou, Zeqi Zheng, Zesheng Xu, Zewei Ouyang, Zeyuan He, Zhan Lv, Zhanquan Li, Zhaofa He, Zheng Ji, Zheng Zhang, Zhenguo Ji, Zhenqi Su, Zhenyu Yang, Zhihong Ou, Zhijian Yang, Zhiming Yang, Zhirong Wang, Zhiyuan Song, Zhongshan Wang, Zuyi Yuan
0Citations signalées, ce qui n’est pas une note de qualité
1Institutions déclarées
1Pays d’affiliation déclarés
Rattachement africain : cn.
Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) have each been associated with bleeding risk; however, their joint association with bleeding outcomes remains insufficiently characterized. We included patients with acute coronary syndrome (ACS) who underwent percutaneous coronary intervention (PCI) and were enrolled in the Improving Care for Cardiovascular Disease in China-ACS project between 2014 and 2019. This study was registered at ClinicalTrials.gov (NCT02306616) on November 29, 2014. Restricted cubic spline analysis assessed dose–response relationships, and multivariable fractional polynomial interaction analysis evaluated lipoprotein interdependence. Heatmaps visualized risk patterns across LDL-C/HDL-C combinations. Among 42,378 patients, 615 in-hospital major bleeding events were recorded. Restricted cubic spline analysis revealed a J-shaped association between HDL-C and bleeding risk, with HDL-C levels below 28 mg/dL associated with a 38% increased bleeding risk (adjusted odds ratio 1.38, 95% CI 1.07–1.79). In the multivariable fractional polynomial interaction analysis, the higher estimated bleeding risk associated with LDL-C < 70 mg/dL was most evident at HDL-C levels below approximately 45 mg/dL ( P for interaction = 0.012), whereas the reverse interaction analysis for HDL-C < 28 mg/dL across continuous LDL-C levels was not statistically significant ( P for interaction = 0.608). Heatmap visualization showed higher estimated bleeding risks when both LDL-C and HDL-C were in lower ranges. In this nationwide ACS registry, HDL-C showed a J-shaped association with in-hospital major bleeding, and LDL-C and HDL-C were jointly associated with in-hospital major bleeding among patients undergoing PCI. Higher estimated risk was observed when both lipoproteins were in lower ranges, consistent with a conditional joint risk pattern.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Joint associations of LDL-C and HDL-C with in-hospital major bleeding in Chinese patients with acute coronary syndrome undergoing PCI: findings from the CCC-ACS project
- Date Crossref
- 27/08/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Les institutions déclarées
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Les sujets associés
Antiplatelet Therapy and Cardiovascular DiseasesBlood properties and coagulationDiabetes, Cardiovascular Risks, and Lipoproteins