Efficacy and clinical outcomes of proximal splenic artery embolization in patients with chemotherapy induced thrombocytopenia
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Le résumé fourni par la source
PURPOSE: This retrospective study aims to investigate efficacy and clinical outcomes of proximal splenic artery embolization (PSAE) in patients with chemotherapy induced thrombocytopenia (CIT). METHODS: PSAE was performed in thirteen patients with CIT (6:7, M:F; median age: 55y; range: 39-76y) with underlying malignancy (colorectal carcinoma: n = 6; pancreatic carcinoma: n = 3; other: n = 4). Median platelet counts were calculated prior to chemotherapy, at nadir resulting in chemotherapy discontinuation, prior to SAE, immediately and at the maximum following SAE. Additionally, the time until re-initiation of chemotherapy was calculated. RESULTS: Technical success was 100%, with no adverse events or 30-day mortality. Vascular plugs (n = 9) and coils (n = 11) were the most frequently used devices. Median platelet count pre-chemotherapy was 201 × 10(9)/L (range: 100-423 × 10(9)/L), platelet count nadir was 45 × 10(9)/L (range: 21-69 × 10(9)/L), and pre-SAE platelet count was 82 × 10(9)/L (range: 45-171 × 10(9)/L). After proximal SAE, median platelet count increased significantly (110 × 10(9)/L; range: 68-169 × 10(9)/L) compared to pre-procedure platelet count (p = 0.027). Median platelet count at the maximum at follow-up was 191 × 10(9)/L (range: 31-518 × 10(9)/L). Chemotherapy was re-initiated after a median of 15 days (range: 7-50d). CONCLUSION: Proximal SAE is a safe and effective treatment option in patients with CIT, with potential benefits in early re-initiation of chemotherapy. Further studies should be conducted to evaluate the longer-term effects of the procedure, further identify eligible patients, and compare to distal SAE.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Efficacy and clinical outcomes of proximal splenic artery embolization in patients with chemotherapy induced thrombocytopenia
- Date Crossref
- 26/08/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Baptist Hospital of Miami pays non établi dans la noticeÉtablissement de santé
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Heidelberg University Department of Vascular and Endovascular Surgery pays non établi dans la noticeUniversité ou école supérieure
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University Hospital Heidelberg pays non établi dans la noticeÉtablissement de santé
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Baptist Health South Florida pays non établi dans la noticeÉtablissement de santé
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Amsterdam Neuroscience pays non établi dans la noticeStructure de recherche
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Amsterdam University Medical Centers pays non établi dans la noticeÉtablissement de santé
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Florida International University pays non établi dans la noticeUniversité ou école supérieure
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Miami Cardiac and Vascular Institute Department of Interventional Radiology pays non établi dans la noticeStructure de recherche
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Miami Cancer Institute Department of Interventional Oncology pays non établi dans la noticeStructure de recherche
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Department of Radiology and Nuclear Medicine pays non établi dans la noticeInstitution
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Herbert Wertheim College of Medicine Department of Interventional Radiology pays non établi dans la noticeUniversité ou école supérieure
Baptist Hospital of Miami, Department of Vascular and Endovascular Surgery — Heidelberg University et University Hospital Heidelberg, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.