Case Series: War-Related Rhabdomyolysis and Acute Kidney Injury in Northwest Syria

Résumé fourni par la source

Introduction Rhabdomyolysis is one of the most serious clinical disorders that can rapidly progress to acute kidney injury, particularly in settings characterized by severe traumatic injuries, excessive physical exertion, or lack of timely medical care. The condition becomes even more critical in regions affected by conflict and disasters, such as Northwestern Syria, due to years of war and the devastating 2023 earthquake. Methods This report presents a series of five diverse cases of rhabdomyolysis complicated by acute kidney injury in northwest Syria from 2016 to 2023, reflecting a broad spectrum of pathophysiological scenarios associated with violence, bombardment, torture, forced detention, displacement, and structural collapse related to natural disasters. Variables describing clinical presentations, creatine kinase levels, serum creatinine, dialysis requirement, interventions, and outcomes were collected from patients' files. Results Despite challenging circumstances and limited availability of advanced medical resources in the region, all patients achieved complete recovery of kidney function. Conclusion These outcomes highlight the importance of early diagnosis, aggressive fluid resuscitation, meticulous laboratory monitoring, and timely initiation of dialysis when indicated. They also underline the ability of local healthcare facilities—despite severe resource constraints—to manage critical cases when evidence-based principles for rhabdomyolysis treatment are applied. This case series underscores the importance of strengthening emergency response systems and disaster preparedness in vulnerable humanitarian settings to reduce morbidity and mortality from this life-threatening condition.

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