Real-world experiences with subcutaneous therapy in adults with primary immune thrombocytopenia: A dual cross-sectional survey study of patients and clinicians in Italy
Rattachement africain : gb, it, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: Thrombopoietin receptor agonists (TPO-RAs) are frequently prescribed as second-line therapy for immune thrombocytopenia (ITP). Approved TPO-RAs have different characteristics that can influence doctor-patient shared decision-making. Objectives: To gain insight into how ITP and its treatment with subcutaneous TPO-RA are perceived by Italian adults with ITP and by treating hematologists. Design: Observational, cross-sectional survey. Methods: Italian national surveys were conducted in adults with ITP receiving subcutaneous TPO-RA treatment for ≥ 3 months, and separately in hematologists with extensive experience treating ITP. The ITP-PAQ questionnaire captured the impact of ITP and treatments. The patient survey assessed self-reported treatment adherence, setting of TPO-RA administration, administration autonomy, and collected demographic and disease-related data. Methodologic limitations include potential selection bias, absence of a comparison group, and reliance on patient-reported adherence. Results: Between December 2023 and February 2024, the surveys were completed by 50 clinicians and 78 patients distributed across Italy; mean patient age 55.5 (±13.7) years, mean disease duration 2.4 (±2.1) years. Patients were receiving subcutaneous ITP treatment for median 7 (minimum 3-maximum 50) months. The mean total ITP-PAQ score was 70.1±8.5, with approximately 80% of patients reporting little or no impact of ITP on overall quality of life. Most patients (51%) self-administered subcutaneous therapy at home; 27% went to hospital. Overall self-reported adherence was 97%. After the first months of treatment, 90% of patients reported being "extremely satisfied"/"satisfied" (68%/22%). This was maintained at survey, when 95% patients were "extremely satisfied"/"satisfied" (72%/23%). Satisfaction was highest with home self-administration (p=0.09). There were no significant differences (90% confidence level) in patients' and clinicians' responses regarding the main advantages of weekly administration. Conclusion: Both patients and specialists indicated that the high satisfaction may be associated with perceived advantages of weekly TPO-RA subcutaneous administration, which may be associated with improved adherence to therapy and reduced medication burden.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Real-world experiences with subcutaneous therapy in adults with primary immune thrombocytopenia: A dual cross-sectional survey study of patients and clinicians in Italy
- Date Crossref
- 01/08/2026
- Éditeur
- SAGE Publications
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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London North West Healthcare NHS Trust pays non établi dans la noticeÉtablissement de santé
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Fondazione Ricerca Molinette pays non établi dans la noticeOrganisation à but non lucratif
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Ospedale San Bortolo pays non établi dans la noticeÉtablissement de santé
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Ospedale Garibaldi pays non établi dans la noticeÉtablissement de santé
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Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori pays non établi dans la noticeStructure de recherche
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Istituti di Ricovero e Cura a Carattere Scientifico pays non établi dans la noticeÉtablissement de santé
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Ospedale Vincenzo Cervello pays non établi dans la noticeÉtablissement de santé
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Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari pays non établi dans la noticeÉtablissement de santé
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Agostino Gemelli University Polyclinic pays non établi dans la noticeÉtablissement de santé
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Catholic University of America pays non établi dans la noticeUniversité ou école supérieure
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Policlinico Umberto I pays non établi dans la noticeÉtablissement de santé
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Azienda USL di Bologna pays non établi dans la noticeÉtablissement de santé
London North West Healthcare NHS Trust, Fondazione Ricerca Molinette et Ospedale San Bortolo, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.