Predictive Power of Pulmonary Artery Stiffness - Right Ventricular Interplay, but not Pulmonary Vascular Resistance, in Mild Pulmonary Hypertension: A PVRI GoDeep meta-registry analysis

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BACKGROUND: ) capture complementary aspects of pulmonary vascular load, whereas stroke volume index (SVI) reflects RV functional adaptation. The prognostic significance of these integrated parameters remains incompletely understood, particularly in early-stage disease. RESEARCH QUESTION: , and SVI predict mortality independently of PVR in patients with mild PH and across the full spectrum of pulmonary hypertension (PH)? METHODS: as end-systolic pressure divided by SV. RESULTS: , PAC, SVI, and heart rate demonstrated independent prognostic value. Expanding the analysis to 16,899 patients across PH groups 1-5, these parameters remained significantly associated with survival, independent of PVR/TPR and after adjustment for multiple potential confounders. Consistent findings were observed across etiological subgroups and IPAH/hPAH. INTERPRETATION: Parameters integrating pulsatile vascular load and interdependent RV function possess predictive power independent of PVR/TPR across the full spectrum of PH. Moreover, they allow meaningful risk stratification in mild PH patients, where conventional parameters lack discriminative prognostic power.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.