Proteome modulation by opposite inotropic drugs in human engineered cardiac tissue revealed by topology-driven cross-modal integration

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Supplementary Figure 1: Four dimensionality reduction methods applied to the entire sample-set (including 0h and 24h)Supplementary Figure 2: Heatmap of pairwise Pearson correlations between metadata using TCN node-level enrichmentSupplementary Figure 3: Pairplot illustrating metadata relationships using TCN node enrichmentSupplementary Figure 4: Customized weighted Voronoi graphs visualizing the results of the pathway enrichment analysis for the untreated samplesSupplementary Figure 5: Customized weighted Voronoi graphs visualizing the results of the pathway enrichment analysis for the DMSO-treated samplesSupplementary Table 1: Results of the node-level correlation analysis across conditions using different correlation thresholdsSupplementary File 1: Settings and details of the proteomics data acquisition and annotation (Proteoscape)Supplementary File 2: Interactive topological connectivity network (TCN)Supplementary File 3: Sample composition of TCN nodesSupplementary File 4: Results of the pathway enrichment analysis (all conditions)Supplementary File 5: Full-scale Voronoi graph for FoC (negatively correlated features)Supplementary File 6: Full-scale Voronoi graph for FoC (positively correlated features)Supplementary File 7: Full-scale Voronoi graph for EPI condition (negatively correlated features)Supplementary File 8: Full-scale Voronoi graph for EPI condition (positively correlated features)Supplementary File 9: Full-scale Voronoi graph for DOXO condition (negatively correlated features)Supplementary File 10: Full-scale Voronoi graph for DOXO condition (positively correlated features)Supplementary File 11: Full-scale Voronoi graph for DMSO condition (negatively correlated features)Supplementary File 12 Full-scale Voronoi graph for DMSO condition (positively correlated features)Supplementary File 13: Full-scale Voronoi graph for UNTREATED condition (negatively correlated features)Supplementary File 14: Full-scale Voronoi graph for UNTREATED condition (positively correlated features)Supplementary Dataset 1: Force of contraction datasetSupplementary Dataset 2: Proteomics datasetSupplementary Dataset 3: Topological node enrichment (TNE) datasetSupplementary Dataset 4: Node-based correlations between proteins and metadata

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