Treating earlier, spending less: cost-effectiveness and budget impact of immediate versus delayed antiretroviral therapy for HIV in Japan

Résumé fourni par la source

A stochastic individual-based dynamic transmission microsimulation of HIV in Japan, linked to a cost-effectiveness and budget-impact analysis from the public-payer perspective. It evaluates permitting immediate ART at diagnosis (relaxing or reforming the statutory immune-dysfunction certification pathway) versus one-month and two-month delays, over a 40-year horizon after a 20-year burn-in. HIV-related mortality is represented by a CD4-stratum by care-state standardised mortality ratio applied to the age- and sex-specific general-population background hazard. The full model specification (ODD protocol) and the complete parameter table are in the article's Supplementary Material.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.