Age-related differences in inflammatory biomarkers and acute kidney injury among hospitalized malaria patients in Luanda, Angola
Rattachement africain : Angola. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Malaria remains a leading cause of morbidity and mortality in sub-Saharan Africa; however, the clinical profiles of older adults with malaria are poorly characterized. Here, we investigated age-related differences in inflammatory burden and acute kidney injury (AKI) among hospitalized patients with malaria in Luanda, Angola. We conducted a cross-sectional study of 518 patients with malaria at two tertiary hospitals in Luanda, Angola, from January 2023 to December 2024. Logistic regression assessed associations between age group and inflammatory burden scores and AKI. Older adults (> 50 years) represented 9.8% of patients with malaria. After multivariable analysis, gender, ABO blood group, hemoglobin S (HbS), parasitemia, and AKI were not associated with age group (p > 0.05). In contrast, moderate [AOR: 0.40 (95% CI: 0.18–0.90), p = 0.028] and high inflammatory burden [AOR: 0.19 (95% CI: 0.04–0.91), p = 0.038] were associated with lower odds of being in the older age group. AKI was more frequent in older adults (35.3% vs 34.7%) and was associated with slightly increased odds (AOR: 1.09; p = 0.842), although this was not statistically significant. Patients over 50 years of age constituted a clinically distinct group among hospitalized malaria cases, characterized by a markedly reduced inflammatory response and a slight increase in acute kidney injury compared to younger patients, despite similar parasitemia. These findings highlight important age-related differences in the pathophysiology of malaria and reinforce the importance of including the elderly in targeted clinical and public health strategies in malaria-endemic areas.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Age-related differences in inflammatory biomarkers and acute kidney injury among hospitalized malaria patients in Luanda, Angola
- Date Crossref
- 22/08/2026
- Éditeur
- Infinity Integrated Publishing Center
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Ministry of Health Angola (code pays fourni par la source)Organisme public
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Agostinho Neto University Institute of Physical Education and Sports (IEFD) Luanda, Angola (code pays fourni par la source)Université ou école supérieure
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Universidade Gregório Semedo Angola (code pays fourni par la source)Université ou école supérieure
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Angola Luanda Luanda, Angola (pays nommé en fin d’affiliation)Organisation à but non lucratif
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Queen Nginga a Mbande University (URNM) Angola (pays nommé en fin d’affiliation)Université ou école supérieure
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Gregório Semedo University (UGS) Luanda, Angola (pays nommé en fin d’affiliation)Université ou école supérieure
Ministry of Health (Angola), Institute of Physical Education and Sports (IEFD) — Agostinho Neto University (Luanda, Angola) et Universidade Gregório Semedo (Angola), avec 3 autres affiliations. Pays d’affiliation : Angola.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.