A Cluster Randomized Controlled Trial to Improve Influenza and Tdap Vaccination Rates for Pregnant Women
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Le résumé fourni par la source
Introduction: We evaluated the impact of a provider and nurse-based intervention on influenza and Tdap vaccination rates among pregnant women. Methods: The VAX-MOM trial was a 2-arm cluster randomized clinical trial conducted across 4 health systems (14 obstetric practices in Rochester, NY, and 13 in Los Angeles, CA), from April 2021 to June 2022. Practices were randomized to receive provider and nurse training via online modules (covering influenza and pertussis infections, vaccination, and workflow changes, such as presumptive vaccine recommendations) or standard care. Co-primary outcomes were influenza and Tdap vaccination rates for women delivering live births during the intervention. Analyses adjusted for clustering within practices. Results: The study included 5992 and 6768 women eligible for Tdap vaccination, and 4609 and 5294 women eligible for influenza vaccination (intervention and control practices, respectively). Influenza vaccination rates declined by 5% in the intervention group (57% to 52%) and by 10% in the control group (57% to 47%). Tdap vaccination rates increased by 3% in both groups (67% to 70% in intervention; 72% to 75% in control). Adjusted analyses showed influenza vaccination rates were 8% higher in intervention practices (aRR 1.08, 95% CI [1.00, 1.15], p = 0.038; not significant given the p < 0.025 cutoff for 2 outcomes). Tdap rates showed no significant difference. Post-hoc analysis excluding one minimally engaged system revealed influenza vaccination rates were 13% higher in intervention practices (aRR 1.13, 95% CI [1.06, 1.19], p < 0.001). Conclusion: Provider and nurse training improved influenza vaccination rates but did not significantly affect Tdap coverage in engaged practices.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- A Cluster Randomized Controlled Trial to Improve Influenza and Tdap Vaccination Rates for Pregnant Women
- Date Crossref
- 22/08/2026
- Éditeur
- SAGE Publications
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Rochester Medicine pays non établi dans la noticeÉtablissement de santé
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Mattel Children's Hospital pays non établi dans la noticeÉtablissement de santé
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Unity Health System pays non établi dans la noticeÉtablissement de santé
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Los Angeles County Department of Health Services pays non établi dans la noticeÉtablissement de santé
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UCLA Health pays non établi dans la noticeÉtablissement de santé
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Centers for Disease Control and Prevention pays non établi dans la noticeOrganisme public
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University of California Department of Pediatrics pays non établi dans la noticeUniversité ou école supérieure
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University of Rochester Medical Center Department of Pediatrics pays non établi dans la noticeUniversité ou école supérieure
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Immunize.org pays non établi dans la noticeInstitution
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Department of Obstetrics and Gynecology pays non établi dans la noticeInstitution
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David Geffen School of Medicine Department of Medicine Statistics Core pays non établi dans la noticeUniversité ou école supérieure
University of Rochester Medicine, Mattel Children's Hospital et Unity Health System, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.