Dietary Fatty Acids, Cardiovascular Disease, and Life Expectancy Among Adults With Adverse Mental Health‐Related Characteristics: A Cohort‐Based Target Trial Emulation Study
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Le résumé fourni par la source
ABSTRACT Adverse mental health‐related characteristics contribute to decreased life expectancy, largely driven by an elevated risk of cardiovascular disease (CVD). Dietary fatty acids influence disease occurrence and progression, yet the associations of polyunsaturated fatty acids (PUFAs) with CVD risk and life expectancy in individuals with adverse mental health‐related characteristics remain unclear. This study focused on individuals with loneliness, anxiety/depression, and neuroticism. In prospective cohort analysis, we found that higher intakes of alpha‐linolenic acid (ALA), stearidonic acid (SDA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) were negatively associated with total CVD risk in individuals with loneliness and anxiety/depression. Target trial emulation analyses further showed that higher EPA and DHA intakes were associated with lower early‐onset CVD risk among participants with loneliness, higher ALA and EPA intakes with lower total CVD risk among those with anxiety/depression, and higher EPA intake with lower early‐onset CVD risk among those with neuroticism. Moreover, higher intakes of n‐3 PUFAs were associated with a gain in life expectancy, ranging from 0.42 to 1.81 years. These findings highlight n‐3 PUFA intake, particularly ALA and EPA, as a dietary factor associated with cardiovascular health and longevity in psychologically vulnerable populations.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Dietary Fatty Acids, Cardiovascular Disease, and Life Expectancy Among Adults With Adverse Mental Health‐Related Characteristics: A Cohort‐Based Target Trial Emulation Study
- Date Crossref
- 22/08/2026
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Kunming Medical University pays non établi dans la noticeUniversité ou école supérieure
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Oil Crops Research Institute pays non établi dans la noticeStructure de recherche
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Tongji Hospital pays non établi dans la noticeÉtablissement de santé
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Huazhong University of Science and Technology pays non établi dans la noticeUniversité ou école supérieure
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Wuhan Children's Hospital pays non établi dans la noticeÉtablissement de santé
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Ministry of Ecology and Environment pays non établi dans la noticeOrganisme public
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Zhengzhou University of Light Industry pays non établi dans la noticeUniversité ou école supérieure
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Hubei Key Laboratory of Lipid Chemistry and Nutrition pays non établi dans la noticeStructure de recherche
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Department of Nutrition and Food Hygiene Hubei Key Laboratory of Food Nutrition and Safety Ministry of Education Key Laboratory of Environment and Health and MOE Key Lab of Environment and Health Key Laboratory of Environment and Health (Wuhan) Ministry of Environmental Protection State Key Laborato pays non établi dans la noticeStructure de recherche
Kunming Medical University, Oil Crops Research Institute et Tongji Hospital, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.