Early-life recurrent antibiotic use and risks of adult kidney cancer and sex-specific cancers: a prospective cohort study in the UK Biobank
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Le résumé fourni par la source
There is little evidence about the associations of long-term or recurrent antibiotics use (LRAU) during early life with cancer risk. Our study aimed to assess the associations via Cox proportional hazards regression, using data from the UK Biobank (UKB). The main outcomes were the incidence of adult kidney cancer and sex-specific cancers, classified according to International Classification of Diseases, 10th revision (ICD-10). LRAU during early life was self-reported. 136,011 participants (55.29% women) were included in the study, with a mean follow-up of 7.5 years (SD 2.17). Among participants with LRAU during early life, a higher proportion were women (68.98% vs. 31.02% men, P < 0.001). Among all participants, LRAU during early life was associated with a higher risk of kidney cancer in the fully adjusted model (HR 1.38; 95% CI 1.05–1.82). No significant associations were observed between LRAU during early life and other non-sex-specific cancers. Sex-stratified analysis revealed that LRAU during early life was associated with an increased risk of kidney cancer (HR 1.59; 95% CI 1.07–2.35), bladder cancer (HR 1.47; 95% CI 1.01–2.13) and breast cancer (HR 1.09; 95% CI 1.00-1.20) in females. For males, LRAU during early life was associated with an increased risk of esophageal cancer (HR 1.72; 95% CI 1.07–2.78). After stratifying the analyses by age at menarche, LRAU during early life was associated with an increased risk of breast cancer among women with menarche after age 12 years (HR 1.15; 95% CI 1.02–1.29), but the interaction effect was not statistically significant ( P for interaction = 0.217). This study provides evidence suggesting that LRAU during early life may be associated with an increased risk of kidney cancer, bladder and breast cancer in adult females, and esophageal cancer in adult males.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Early-life recurrent antibiotic use and risks of adult kidney cancer and sex-specific cancers: a prospective cohort study in the UK Biobank
- Date Crossref
- 22/08/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Dongguan People’s Hospital Department of Operations and Performance pays non établi dans la noticeÉtablissement de santé
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Shandong University Center for Clinical Epidemiology and Evidence-Based Medicine pays non établi dans la noticeUniversité ou école supérieure
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Shandong Provincial Hospital Department of Human Resources pays non établi dans la noticeÉtablissement de santé
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Shandong First Medical University pays non établi dans la noticeUniversité ou école supérieure
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Shandong Tumor Hospital pays non établi dans la noticeÉtablissement de santé
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School of Fine Arts pays non établi dans la noticeUniversité ou école supérieure
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School of Public Health Department of Epidemiology pays non établi dans la noticeUniversité ou école supérieure
Department of Operations and Performance — Dongguan People’s Hospital, Center for Clinical Epidemiology and Evidence-Based Medicine — Shandong University et Department of Human Resources — Shandong Provincial Hospital, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.