BIOCARD framework: integrating fecal bile acids, lipids, and metabolites to assess response to a cardiovascular health intervention
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Le résumé fourni par la source
Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality, particularly in under-resourced populations. Although nutritional interventions are important for CVD prevention, their outcomes are commonly evaluated using conventional clinical and behavioral indicators, which may not fully capture early molecular responses. In this study, we developed the BIOCARD framework, an exploratory fecal multi-omics platform integrating bile acids, lipids, and metabolites to evaluate intervention outcomes related to cardiovascular health. Fecal samples were collected from caregiver-child participants enrolled in a 10-week randomized controlled trial comparing a multicomponent garden-based intervention (SHA) with an education-only control group (MSP). Fecal polar metabolites, lipids, and bile acids were analyzed by UHPLC-HRMS-based approaches and integrated with conventional health indicators. Traditional clinical indicators in the present study showed limited sensitivity for detecting intervention-related differences. In contrast, fecal multi-omics analyzes revealed intervention-associated differences in metabolites, lipids, and bile acids, with children showing more apparent molecular variation than parents. Network analysis further revealed associations between selected molecular features and cardiovascular-related indicators, including blood pressure, body fat, skin carotenoids, and Healthy Eating Index scores. Together, these findings suggest that the BIOCARD framework may serve as an exploratory molecular approach to complement traditional outcome measures and improve the evaluation of nutritional interventions for cardiovascular health.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- BIOCARD framework: integrating fecal bile acids, lipids, and metabolites to assess response to a cardiovascular health intervention
- Date Crossref
- 21/08/2026
- Éditeur
- Informa UK Limited
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute Department of Human Sciences pays non établi dans la noticeÉtablissement de santé
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The Ohio State University pays non établi dans la noticeUniversité ou école supérieure
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Nationwide Children's Hospital Primary Care Pediatrics pays non établi dans la noticeÉtablissement de santé
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New York State University College of Human Ecology pays non établi dans la noticeUniversité ou école supérieure
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University of Illinois Urbana-Champaign pays non établi dans la noticeUniversité ou école supérieure
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Academy of Nutrition and Dietetics pays non établi dans la noticeOrganisation à but non lucratif
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Abigail Wexner Research Institute Center for Child Health Equity and Outcomes Research pays non établi dans la noticeStructure de recherche
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College of Medicine Department of Pediatrics pays non établi dans la noticeUniversité ou école supérieure
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College of Education and Human Ecology pays non établi dans la noticeUniversité ou école supérieure
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University of Illinois at Urbana-Champaign Department of Animal Sciences pays non établi dans la noticeUniversité ou école supérieure
Department of Human Sciences — The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University et Primary Care Pediatrics — Nationwide Children's Hospital, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.