Comparative Experimental and Viscoelastic Modeling Study of Human Tibial Trabecular Bone Under Healthy and Osteoarthritic Conditions

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Background: The development of osteoarthritis (OA), a whole-joint disorder that is increasingly recognized, depends on subchondral trabecular bone. Variations in the viscoelastic characteristics of trabecular bone have been proposed to affect load distribution and potentially lead to joint degradation. The viscoelastic response of human trabecular bone in both healthy and osteoarthritic situations was investigated using constitutive modeling and stress-relaxation testing. Fifteen tibial trabecular bone specimens were evaluated using Standard Linear Solid (SLS) models and two-branch generalized Maxwell models following uniaxial stress-relaxation testing. Mechanical, energy, and relaxation-related traits were retrieved and compared between groups. Results: Healthy bone tended to relax stress more slowly and to bear mechanical loads over time to a slightly greater extent than osteoarthritic bone, which tended to relax stress more quickly and had poorer mechanical endurance; these differences were not statistically significant. The Generalized Maxwell model suited the experimental data better than the SLS model (R2 > 0.98), capturing both short- and long-term relaxation mechanisms. Sensitivity analysis revealed higher parameter variability in OA specimens, suggesting possible differences in mechanical heterogeneity and load-dissipation behavior that require further investigation. Conclusions: Although the observed differences were not statistically significant in this exploratory study, the results suggest potential trends toward altered viscoelastic behavior between healthy and osteoarthritic trabecular bone. Future studies with larger cohorts are needed to further investigate osteoarthritis-related biomechanical alterations. Multi-branch viscoelastic modeling may provide sensitive mechanical descriptors for characterizing the relaxation behavior of subchondral bone.

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