Primary infection with a Brazilian chikungunya virus isolate protects immunocompetent mice against detectable viremia following homologous rechallenge
Rattachement africain : br, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Chikungunya virus (CHIKV) is an arthropod-borne virus responsible for an acute febrile illness characterized by severe polyarthralgia, predominantly affecting peripheral joints. In a substantial proportion of patients, these symptoms may progress to chronic manifestations that significantly impair quality of life. Animal models are therefore critical for the development of effective therapeutic and preventive strategies, including antiviral agents and vaccines. In this context, the aim of this study was to establish an experimental model of CHIKV infection using immunocompetent C57BL/6 mice. Animals were infected with CHIKV and subsequently monitored for clinical signs, viremia, viral dissemination across tissues, total leukocyte counts, and susceptibility to reinfection. Results revealed no deaths among the animals during the experimental period, and infected animals exhibited significant viremia as well as detectable viral loads in the popliteal lymph node, femoral bone marrow, and muscle, demonstrating CHIKV capacity to disseminate and reach multiple target tissues. In addition, a global reduction in leukocyte counts was observed in infected mice. Notably, animals previously infected with CHIKV were resistant to reinfection, indicating the establishment of a protective immune response, as evidenced by the presence of neutralizing antibodies. In conclusion, the murine model established in this study recapitulates key features of CHIKV infection and provides a robust platform for investigating viral pathogenesis, as well as for evaluating novel antiviral strategies and vaccine candidates.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Primary infection with a Brazilian chikungunya virus isolate protects immunocompetent mice against detectable viremia following homologous rechallenge
- Date Crossref
- 20/08/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Universidade Federal do Oeste da Bahia pays non établi dans la noticeUniversité ou école supérieure
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Universidade Estadual de Santa Cruz pays non établi dans la noticeUniversité ou école supérieure
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Universidade Federal de Minas Gerais pays non établi dans la noticeUniversité ou école supérieure
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University of Wisconsin–Madison pays non établi dans la noticeUniversité ou école supérieure
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Federal University of Western Bahia Western Bahia Virology Institute pays non établi dans la noticeUniversité ou école supérieure
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State University of Santa Cruz Department of Biological Sciences pays non établi dans la noticeUniversité ou école supérieure
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Federal University of Minas Gerais Virus Bioinformatics Laboratory pays non établi dans la noticeUniversité ou école supérieure
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School of Medicine and Public Health Department of Dermatology pays non établi dans la noticeUniversité ou école supérieure
Universidade Federal do Oeste da Bahia, Universidade Estadual de Santa Cruz et Universidade Federal de Minas Gerais, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.