Significant cough severity in patients with low objective cough frequency

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Introduction: An objective hourly cough frequency (CF) of ≥20 is often an inclusion criterion in anti-tussive clinical trials; however, the burden of cough at lower CF is unknown. We assessed the severity and impact of chronic cough (CC) in all patients and those with an objective hourly CF <20. Methods: Consecutive unselected patients with CC from an ERS NEuroCOUGH CRC site completed assessments: 24hr objective CF monitoring (Leicester Cough Monitor), cough severity visual analogue scale (VAS; 0-100 mm) and cough-specific health status Leicester Cough Questionnaire (LCQ; 3-21). Results: A total of 147 patients completed assessments; median (IQR) age 54 (43-66) years, 65% female, duration of cough 24 (8-60) months, and 45 (31%) refractory CC. Patients had geometric mean (SD) CF 10.4 (2.8) c/hr, and median (IQR) VAS 50 (24-74) mm and LCQ score 12.4 (8.5 – 16.0). 102 (61%) patients had CF <20 c/hr, of which 51 (50%) and 50 (49%) had moderate or higher cough severity and health status impairment; median (IQR) VAS 40 (20-72) mm and LCQ score 13.3 (9.1-17.5), respectively (Fig 1). 86 (59%) of all patients had at least moderate VAS severity, but only 51 (59%) of them had CF <20 c/hr. Discussion: The majority of patients referred for assessment of CC have CF <20 c/hr, of which ~50% had moderate or higher cough severity and QoL impairment. The objective CF threshold of ≥20 c/hr in clinical trials may restrict patient access to novel therapies and other objective cough parameters should be investigated as outcome measures. erjor;12/suppl_20/OP9/F1 F1 F1

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