Effects of Walnut ( Juglans regia L.) on Blood Pressure and Endothelial Function in Adults: A Systematic Review and Dose–Response Meta‐Analysis
Rattachement africain : ir, ua. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Walnuts (Juglans regia L.) are rich in bioactive compounds with anti-inflammatory and antioxidant properties, which may benefit cardiovascular health. However, the evidence regarding their effects on blood pressure (BP) and endothelial function remains inconclusive. OBJECTIVE: This systematic review and meta-analysis aimed to evaluate the effects of walnut consumption on systolic and diastolic BP (SBP and DBP), and endothelial function markers, including flow-mediated dilation (FMD), intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in adults. METHODS: A systematic search of PubMed, Web of Science and Scopus was conducted through February 2026 to identify relevant randomized controlled trials (RCTs). Weighted mean differences (WMDs) with corresponding 95% confidence intervals (CIs) were estimated using a random-effects model. Subgroup analyses were conducted based on intervention duration and walnut dosage. Dose-response associations were further examined using both linear and nonlinear modelling approaches. RESULTS: Pooled analysis data from 36 RCTs showed no significant overall effect of walnut consumption on SBP (WMD: -0.65 mmHg; 95% CI: -1.61 to 0.30, p = 0.183) or DBP (WMD: -0.68 mmHg; 95% CI: -1.56 to 0.19, p = 0.125). However, significant reductions in DBP were observed in studies lasting ≥ 12 weeks. Walnut intake significantly increased FMD (WMD: 0.93%; 95% CI: 0.27 to 1.59, p = 0.006), but had no overall significant effect on ICAM-1 (WMD = -0.56 ng/mL; 95% CI: -2.50 to 1.38; p = 0.571) and VCAM-1 (WMD: -8.68 ng/mL, p = 0.663). Subgroup analysis indicated a reduction in ICAM-1 in participants at high cardiovascular risk. The dose-response analysis supported a greater effect on ICAM-1 at higher walnut intakes. CONCLUSION: Walnut supplementation may improve vascular health by reducing endothelial dysfunction and promoting a dose-dependent reduction in endothelial inflammation. TRIAL REGISTRATION: International Prospective Register of Systematic Reviews (PROSPERO): CRD420261461684.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Effects of Walnut ( <i>Juglans regia</i> L.) on Blood Pressure and Endothelial Function in Adults: A Systematic Review and Dose–Response Meta‐Analysis
- Date Crossref
- 01/08/2026
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Kerman University of Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Ahvaz Jundishapur University of Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Bogomolets National Medical University pays non établi dans la noticeUniversité ou école supérieure
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Shahid Beheshti University of Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Iran University of Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Shiraz University of Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Yasuj University of Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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School of Medicine Ahvaz Jundishapur University of Medical Science Ahvaz Iran pays non établi dans la noticeUniversité ou école supérieure
Kerman University of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences et Bogomolets National Medical University, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.