Management of Pediatric Crohn’s Disease: an ECCO-ESPGHAN Guideline Update
Rattachement africain : il, hr, it, ch, fi, nl, ca, gb, ie, es, cz. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
OBJECTIVE: To provide an updated, evidence-based European Crohn's and Colitis Organisation [ECCO]-European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN] guideline for the management, monitoring, and long-term care of pediatric Crohn's disease [CD]. METHODS: A multidisciplinary panel of 27 experts followed ECCO Standard Operating Procedures for guideline development. A systematic review of studies published between January 2018 and October 2024, with targeted updates through June 2025, was conducted across MEDLINE, EMBASE, and Cochrane Central. Evidence was graded using the Oxford Centre for Evidence-Based Medicine levels. Draft statements underwent two Delphi voting rounds involving the guideline panel, ECCO National Representatives, and an international sounding board; statements achieving ≥80% agreement were accepted. RESULTS: This guideline provides updated recommendations across major domains of pediatric CD care, including risk stratification, treatment targets, induction and maintenance strategies, nutritional therapies, therapeutic drug monitoring, and the roles of imaging and endoscopy. High-risk patients should start anti-TNF therapy as first-line treatment, with proactive and reactive therapeutic drug monitoring to enhance efficacy. For low-risk luminal disease, exclusive enteral nutrition or the Crohn's Disease Exclusion Diet with partial enteral nutrition are preferred induction options. Long-term management emphasizes achieving endoscopic remission, normal growth, improved quality of life, and reduction of bowel damage. This guideline also reviews emerging advanced therapies, including biologics and small molecules, which are increasingly used in practice but generally not yet approved for pediatric CD, to inform clinicians about their potential role. CONCLUSIONS: This updated ECCO-ESPGHAN guideline integrates new pediatric evidence with contemporary adult data and treat-to-target principles, providing practical recommendations to support personalized, multidisciplinary, and proactive management aimed at improving long-term outcomes in pediatric CD.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Management of Pediatric Crohn’s Disease: an ECCO-ESPGHAN Guideline Update
- Date Crossref
- 01/08/2026
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Tel Aviv University pays non établi dans la noticeUniversité ou école supérieure
-
Schneider Children's Medical Center pays non établi dans la noticeÉtablissement de santé
-
Children's Hospital Zagreb pays non établi dans la noticeÉtablissement de santé
-
Federico II University Hospital pays non établi dans la noticeÉtablissement de santé
-
University of Naples Federico II pays non établi dans la noticeUniversité ou école supérieure
-
University Hospital of Bern pays non établi dans la noticeÉtablissement de santé
-
Shaare Zedek Medical Center pays non établi dans la noticeÉtablissement de santé
-
University of Helsinki Department of Pediatric Gastroenterology pays non établi dans la noticeUniversité ou école supérieure
-
Helsinki University Hospital pays non établi dans la noticeÉtablissement de santé
-
Helsinki Children's Hospital pays non établi dans la noticeÉtablissement de santé
-
Wolfson Medical Center Pediatric Gastroenterology and Nutrition Unit pays non établi dans la noticeÉtablissement de santé
-
University Medical Center Groningen pays non établi dans la noticeÉtablissement de santé
Tel Aviv University, Schneider Children's Medical Center et Children's Hospital Zagreb, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.