Coordinated behavioural and neural variability in hippocampal reward coding

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Abstract An environment can be interpreted in multiple ways, with implications for behaviour and neural representations and for revision in these when circumstances change. Using two-photon calcium imaging in mouse CA1 during navigation under structured reward-location uncertainty, we found correlations between variability in anticipatory behaviour and the organization of place fields with respect to position and reward. Greater spatial anticipation was associated with enhanced reward-centred coding and increased generalisability of reward-aligned representations.

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