Boston Criteria 2.0 stratifies hemorrhage location within mixed intracerebral hemorrhage: external validation of CADMUS small vessel disease classification
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Le résumé fourni par la source
BACKGROUND: CADMUS is an MRI-based classification for small vessel disease (SVD) related intracerebral hemorrhage (ICH), providing distinct SVD phenotypes: cerebral amyloid angiopathy (CAA), deep perforator arteriopathy (DPA), Mixed CAA-DPA, and Undetermined SVD. We evaluated construct validity in an external cohort by examining whether CADMUS subtypes demonstrate biologically coherent anatomical distributions, and whether lobar hematoma location is associated with probable CAA within the mixed ICH subtypes: Mixed CAA-DPA and Undetermined SVD. METHODS: Cross-sectional analysis of patients with first-ever spontaneous ICH admitted to a tertiary hospital (2008-2024). Location was classified as lobar supratentorial, deep/non-lobar supratentorial, or infratentorial. Differences in hematoma location across CADMUS subtypes were assessed by chi-square with Bonferroni-corrected pairwise comparisons. Within the mixed ICH subtypes, we assessed whether lobar hemorrhage location was associated with Probable CAA according to the Boston Criteria 2.0. RESULTS: = 394.2, p < 0.001): CAA was exclusively lobar and DPA exclusively deep or infratentorial. Among patients with a mixed ICH subtype, those with lobar hemorrhage location were more likely to have Probable CAA criteria than those with a non-lobar hemorrhage: 63/262 (24.0%) of lobar patients were Boston-probable compared with 1/232 (0.4%) of non-lobar patients OR 73.1 (95% CI 10-534, p < 0.001). CONCLUSIONS: CADMUS subtypes demonstrate near-complete anatomical segregation in an independent external cohort. Among patients with a mixed ICH subtype, lobar hemorrhage location was strongly associated with Probable CAA, supporting its use as a potential marker of CAA in this population.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Boston Criteria 2.0 stratifies hemorrhage location within mixed intracerebral hemorrhage: external validation of CADMUS small vessel disease classification
- Date Crossref
- 01/11/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Dartmouth–Hitchcock Medical Center pays non établi dans la noticeÉtablissement de santé
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Beth Israel Deaconess Medical Center Department of Neurology pays non établi dans la noticeÉtablissement de santé
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Harvard University pays non établi dans la noticeUniversité ou école supérieure
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Cape Cod Hospital Division of Neurology pays non établi dans la noticeÉtablissement de santé
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Geisel School of Medicine at Dartmouth Department of Neurology pays non établi dans la noticeUniversité ou école supérieure
Dartmouth–Hitchcock Medical Center, Department of Neurology — Beth Israel Deaconess Medical Center et Harvard University, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.