Effectiveness of Brief Psychological Intervention for Depression in Pregnancy (BIND-P): A multi-centric randomized controlled trial (RCT)

Résumé fourni par la source

Background: Depression is the most prevalent psychiatric disorder among women during pregnancy but often goes undetected and untreated. Aim: This study aimed to assess whether a brief psychological intervention for depression in pregnancy (BIND-P) delivered by nurses is efficacious in the treatment of depression as compared to Treatment as Usual (TAU). Methods: A multi-centric, hospital-based open-label parallel group, randomized controlled trial was conducted at four sites across India (one each in Northern and Central India, and two in Southern India) from 2018 to 2022. A total of 1,352 participants were randomly allocated (1:1) to BIND-P and TAU groups. The primary outcome assessment was a reduction in PHQ-9 scores (from baseline to 8 weeks post recruitment). The secondary outcome was the outcome of pregnancy and infant development at 6/10/14 weeks post pregnancy. Results: = 0.91). The overall effect size was small (Cohen's d ≈ 0.05). Discontinuation rates were lower in the BIND-P group compared to TAU (17.34% vs 30.35%). Subgroup analyses suggested greater likelihood of remission among women who were older, had higher education, were from rural settings, had lower income, were primigravida, or had high-risk pregnancies. No significant differences were observed between groups in pregnancy or infant outcomes. Conclusion: The BIND-P intervention was not inferior to TAU in reducing depressive symptoms but demonstrated lower discontinuation rates. As a low-intensity psychosocial intervention (LIPI), BIND-P may be a feasible and acceptable option for integration into routine maternal healthcare services, with potential to help reduce the treatment gap in perinatal mental health.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.