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Early written exposure therapy after traumatic events: The 2-ASAP WEP Study

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We preregister the following aims of the 2-ASAP WEP (Written Exposure Prevention) study: The primary objective of the present study is to investigate the effectiveness of Written Exposure Therapy (WET) as a selective, preventive intervention against chronic PTSD (symptom severity) in individuals who have recently been exposed to a potentially traumatic event (PTE) and who appear to have an increased risk for long-term PTSD. Therefore, the primary outcome measure is the severity of PTSD symptoms, assessed with the PCL-5 across the monthly follow-up assessments compared to the control condition. Secondary aims include assessing the presence of a PTSD diagnosis at the final assessment (CAPS-5-R), wellbeing (WHO-5), severity of trauma-related comorbid symptoms such as anxiety, depression (DASS-21), substance use (MATE-Q), and quality of life (WHOQOL-BREF). Furthermore, cost-effectiveness (iMCQ, iPCQ, EQ-5D-5L), as well as acceptability (TFA-Q) of WET will be investigated. WET is a brief psychotherapeutic intervention aimed at reducing PTSD symptoms. Our WET intervention includes five guided-writing sessions (first session 60 min., second until fifth session 45 min.) spread over a period of three weeks. During each session, participants receive instructions for writing assignments of approximately 30 minutes via video call. In all five sessions, participants repeatedly write by hand about their memories, thoughts, and feelings related to one specific PTE. Each writing session is guided online by a trained healthcare provider, who is present throughout the entire session. The WET instructions are defined in a semi-structured protocol, which is read aloud by the healthcare provider at the beginning and throughout each session. At the start of each subsequent session, the healthcare provider gives feedback on the previously written texts. With the help of this feedback participants can improve writing from session to session. This preregistration is based on the study protocol, whose online registration can be found here: https://onderzoekmetmensen.nl/en/trial/58551

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