Altered functional connectivity in neural circuits of bipolar disorder and problematic gaming: a resting-state fMRI study
Rattachement africain : cn, jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Problematic gaming (PG) represents an addictive behavior that is prevalent among young adults and has a significant impact on mental health. Patients diagnosed with bipolar disorder (BD) may be particularly susceptible to PG. Nevertheless, the neural circuits underlying PG in patients with BD remain poorly understood. A total of 73 participants were included in this study, including the group of BD patients with PG (BD-PG, n = 26), the group of BD patients without PG (BD-NPG, n = 23), and the healthy control group (HC, n = 24). All participants completed the VGD-S and underwent resting-state fMRI scanning, while BD patients additionally completed the BDI-II and YMRS within 24 h before scanning. Seed-based functional connectivity (FC) related to cognitive control, emotion, and reward was examined. ANCOVA, FDR correction, a separate BD sensitivity analysis, and partial correlation analysis were performed. After FDR correction, FC between the left thalamus and right amygdala was increased in the BD-PG group compared with both the BD-NPG and HC groups and was also increased in the BD-NPG group compared with the HC group. Partial correlation analysis further showed that FC between the left thalamus and right amygdala was positively associated with VGD-S scores after controlling for age, education years, and medication burden. Increased FC between the left thalamus and right amygdala may represent a preliminary neural correlate of problematic gaming severity among patients with BD. This finding may suggest the potential importance of the thalamus and amygdala in cognitive control and reward processing in BD patients with PG.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Altered functional connectivity in neural circuits of bipolar disorder and problematic gaming: a resting-state fMRI study
- Date Crossref
- 16/08/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Central South University Department of Psychiatry pays non établi dans la noticeUniversité ou école supérieure
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Second Xiangya Hospital of Central South University pays non établi dans la noticeÉtablissement de santé
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University of Tsukuba Institute of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Tsukuba International University pays non établi dans la noticeUniversité ou école supérieure
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Huazhong University of Science and Technology pays non établi dans la noticeUniversité ou école supérieure
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Tongji Medical College of Huazhong Department of Sleep Medicine pays non établi dans la noticeUniversité ou école supérieure
Department of Psychiatry — Central South University, Second Xiangya Hospital of Central South University et Institute of Medicine — University of Tsukuba, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.