Figure S1-S11 from Integrated Multiomic Profiling Enhances Risk Stratification and Prognostication in Canine Osteosarcoma

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Supplementary Figure 1 | The total sample size for each clinical trial, the treatments received, and the number of multiomic samples associated with each COTC021/022 /030 cohort. Supplementary Figure 2 | The detailed parameter and steps used in copy number variation, single nucleotide and structural variation. Supplementary Figure 3 | Genetic profiling of Discovery cohort patients (n = 55). Supplementary Figure 4 | Forest plots of adjusted hazard ratios for TP53 stratification and clinical features derived from multivariable Cox proportional hazards regression analyses. (a) Disease-free interval (DFI). (b) Overall survival (OS). *P < 0.05 Supplementary Figure 5 | Genetic profiling of Expansion cohort patients (n = 209). Supplementary Figure 6 | Consensus matrix of control and primary OS WGBS samples using K value 2 to 10. Supplementary Figure 7 | Forest plots of adjusted hazard ratios for methylation stratification and clinical features derived from multivariable Cox proportional hazards regression analyses. (a) Disease-free interval (DFI). (b) Overall survival (OS). *P < 0.05. Supplementary Figure 8 | Forest plots of adjusted hazard ratios for MYC stratification and clinical features derived from multivariable Cox proportional hazards regression analyses. (a) Disease-free interval (DFI). (b) Overall survival (OS). *P < 0.05 Supplementary Figure 9 | Box plots represent distribution of SBS in MYC-amplified (n = 31) and MYC-unamplified (n = 24) tumors. Supplementary Figure 10 | Heatmap depicting the fraction of MTAP stratified patients (with MTAP deletion: n = 31 and without MTAP deletion n = 24) grouped into TME subtype (IE, IE-ECM, and ID). IE = Immune Enriched, IE-ECM = Immune Extracellular Matrix, ID = Immune Dessert. Supplementary Figure 11 | Forest plots of adjusted hazard ratios for PTEN stratification and clinical features derived from multivariable Cox proportional hazards regression analyses. (a) Disease-free interval (DFI). (b) Overall survival (OS). *P < 0.05.

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