Interactions between human milk components and infant polygenic risk predict childhood atopy
Rattachement africain : ca, us, fr. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Background Although human milk (HM) confers important health benefits, how bioactive milk components (e.g., microbiota, oligosaccharides, and fatty acids) interact with infant genetics to influence childhood atopy remains poorly understood. Objective We investigated interactions between infant genomic susceptibility and exposure to maternal human milk components (HMCs) and assessed whether integrating these genetic and milk features improves prediction of childhood atopy. Methods Leveraging infant genomic and maternal HMC data from the CHILD Cohort Study, we conducted gene-milk interaction analysis using linear regression models that integrated polygenic risk scores (PRS) of nursing infants with multiple HMC types. Gradient-boosting machines (GBMs) were used to evaluate predictive performance of HMCs and infant PRS for childhood atopy. Results Childhood atopy was associated with interactions between infant genomics (e.g., PRS associated with atopy) and exposure to specific human milk microbes (e.g., Abiotrophia , P Bonf =0.005, β=0.29), as well as networks of co-occurring HMCs (e.g., a module containing Bifidobacterium longum , 2’-fucosyllactose, and eicosapentaenoic acid, P=0.009, β=-12.3). A GBM integrating HMCs and infant PRS achieved the highest predictive performance for childhood atopy with an area under the curve (AUC) of 0.78, outperforming models based on individual HMC types or PRS alone (AUC range: 0.54-0.63). Conclusion Integration of maternal HMC exposures with infant genomics reveals interaction effects that contribute to prediction of childhood atopy. Understanding how early-life exposures such as HMCs impact the health of children differently depending on their genomic profiles may facilitate the development of personalized intervention strategies to reduce the burden of these health outcomes during childhood. Key messages Interactions between infant polygenic risk and exposure to human milk components are associated with childhood atopy. Networks of co-occurring human milk microbiota, oligosaccharides, and fatty acids may influence childhood atopy, with effects varying by infant genomic susceptibility. Integration of human milk components with infant genomics improves prediction of childhood atopy compared with individual milk components or genomics alone. Capsule Summary This study demonstrates that interactions between infant polygenic risk and maternal milk components improve prediction of childhood atopy, highlighting opportunities for personalized early-life prevention strategies.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Interactions between human milk components and infant polygenic risk predict childhood atopy
- Date Crossref
- 13/08/2026
- Éditeur
- openRxiv
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Queen's University Dept. of Biomedical and Molecular Sciences pays non établi dans la noticeUniversité ou école supérieure
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BC Children's Hospital pays non établi dans la noticeÉtablissement de santé
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Mothers’ Milk Bank pays non établi dans la noticeOrganisation à but non lucratif
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University of Toronto Dept. of Nutritional Sciences pays non établi dans la noticeUniversité ou école supérieure
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University of Alberta Food and Nutritional Science pays non établi dans la noticeUniversité ou école supérieure
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Manitoba Health pays non établi dans la noticeÉtablissement de santé
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Children's Hospital Research Institute of Manitoba Manitoba Interdisciplinary Lactation Centre (MILC) pays non établi dans la noticeÉtablissement de santé
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University of Manitoba Dept. of Pediatrics and Child Health pays non établi dans la noticeUniversité ou école supérieure
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Hospital for Sick Children Dept. of Pediatrics pays non établi dans la noticeÉtablissement de santé
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Institut de Recherche en Santé Digestive pays non établi dans la noticeStructure de recherche
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Public Health Ontario pays non établi dans la noticeÉtablissement de santé
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McMaster University Farncombe Family Digestive Health Research Institute pays non établi dans la noticeUniversité ou école supérieure
Dept. of Biomedical and Molecular Sciences — Queen's University, BC Children's Hospital et Mothers’ Milk Bank, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.