Chemical study and investigation of the larvicidal activity of metabolites produced by the endophytic fungus Colletotrichum siamense

Le résumé fourni par la source

Microorganisms can produce a wide range of secondary metabolites with different activities, including larvicidal activities. Colletotrichum is a widespread fungal genus worldwide, and some species of this genus can establish mutualistic interactions with plants. In this study, the endophytic fungus Colletotrichum siamense was isolated from the hemiparasitic plant Passovia stelis to evaluate the chemical profile of the microorganism and its larvicidal activity against Aedes aegypti. This mosquito is one of the main transmitters of arboviruses, and the use of synthetic insecticides to fight the mosquito has generated resistance in its populations. For the larvicidal tests, the organic extract of fungal metabolites was obtained by partitioning with ethyl acetate after the cultivation of C. siamese in potato dextrose broth. The assay results indicated that the C. Siamese extract was active against Ae. aegypti, with an LC50 of 248 µg/mL for a 72-hour treatment. The extract was then subjected to chemical dereplication using the Global Natural Products Social Molecular Networking (GNPS) platform. The metabolites culmorin and cytochalasin D were found in the extract, the latter of which is representative of a biosynthetic class with previously reported activities against Aedes aegypti larvae.

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