Code and derived data for "AGR2 tracks mucin-client demand across adenocarcinomas, revealing lineage-tuned proteostasis"

Résumé fourni par la source

This record contains the derived data and analysis code supporting the manuscript “AGR2 tracks mucin-client demand across adenocarcinomas, revealing lineage-tuned proteostasis.” The study investigates whether deployment of the endoplasmic-reticulum protein disulfide isomerase AGR2 is quantitatively coupled to lineage-specific secretory client demand rather than simply to generic ER folding and redox machinery across epithelial cancers. The archive contains: the locked per-sample score table used for manuscript-level analyses (Supplementary Data S1); derived statistical and cohort-level analysis tables; gene-set and scoring definitions; Python analysis scripts and archived analysis notebooks; scripts used to reconstruct figures and supplementary tables; reliability-matched null analyses and dependent-correlation tests; lineage- and molecular-subtype analyses; EMT and proteostasis-module analyses; GDF15-related analyses; patient-level single-nucleus and spatial analyses; documentation of dataset provenance, local input mapping and computational dependencies. The submitted analyses use the locked 22-gene AGR3-free SecretoryFactor definition. Primary third-party expression, proteomic, single-cell and spatial datasets are not redistributed in this archive. Their originating public repositories, accession identifiers and local analysis-input mappings are documented in docs/DATA_SOURCES.md and docs/INPUT_FILE_MAP.tsv. Figure-level Source Data are submitted separately with the manuscript and are not duplicated in this archive

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.