Ventricular‐vascular coupling at rest and immediately following maximal exercise in adults with and without multiple sclerosis

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Abstract Multiple sclerosis (MS) may impair ventricular‐vascular coupling (VVC), a measure of the interaction between the cardiac and vascular systems. We evaluated if VVC differed between individuals with and without MS with similar age‐predicted fitness. Individuals with MS ( n = 20) and without (CON, n = 18) underwent VVC measurement before and immediately after a maximal incremental cycle test with peak oxygen consumption (VO 2 peak) measurement. VVC was quantified as the ratio of arterial elastance (E A : end‐systolic pressure (ESP)/stroke volume) to ventricular elastance (E LV : ESP/end‐systolic volume). ESP was assessed with radial applanation tonometry, and cardiac volumes were obtained from apical four‐chamber echocardiography. Sex, BMI and VO 2 peak were not different between groups. Individuals with MS were older, had higher E A ( p < 0.01) and E LV ( p = 0.02), but VVC did not differ between groups. After adjustment for age, the group differences in E A and E LV remained significant. VVC was similar between individuals with and without MS, before and immediately after maximal exercise. However, individuals with MS had higher E A and E LV , suggesting higher arterial and ventricular loads. Our data suggest that individuals with MS with similar fitness to controls exhibit higher E A and E LV with preserved coupling.

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