Symptom-specific impacts of major depressive disorder on everyday life: a systematic review of qualitative research evidence
Le résumé fourni par la source
Background: Treatment for major depressive disorder (MDD) is typically assessed in terms of total symptom reduction. Nevertheless, some symptoms, such as cognitive dysfunction and sleep disturbances, may persist residually, leading to ongoing difficulties in daily life. Understanding symptom-specific effects is crucial for supporting functional recovery and developing targeted treatment strategies. To our knowledge, this is the first systematic review to synthesise qualitative evidence on how specific symptoms impact functioning throughout MDD.Aim: We aim to identify and synthesise the lived experiences of specific depressive symptoms (e.g., cognitive difficulties, sleep disturbances) across the course of MDD and how these affect everyday functioning. Method: Prospective registration will be undertaken on PROSPERO. Five databases will be systematically searched [PubMed, PsycArticles, PsycINFO, Medline (Ovid), and Web of Science] for qualitative studies since database inception. Study selection will follow predefined eligibility criteria, completed independently by two reviewers. Findings will be analysed using a thematic synthesis approach, with the quality of evidence assessed. Results: Key concepts guiding pilot searches include “depression,” “residual symptoms,” and “functioning.” The finalised search strategy will be run with study selection, then undertaken within the first quarter of 2026, with all steps reported according to PRISMA guidelines. Participant quotes and author interpretations will be inductively coded and synthesised into overarching themes capturing experiences of specific symptoms throughout MDD. Conclusion: Findings will underscore the importance of assessing symptom-specific experiences and developing targeted interventions to enhance functional recovery and refine treatment strategies in MDD.
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