Dataset: Cost-Effectiveness and Budget Impact Analyses of Strategies to Improve Measles Vaccination Coverage in Kenya

Résumé fourni par la source

This dataset comprises a static Markov model, developed in Microsoft excel, used to assess the cost-effectiveness of measles vaccination strategies in Kenya. The model applies annual cycles over the 10-year time horizon, with a new birth cohort entering the model each year.At birth, children are assumed to be protected by maternal antibodies (MI). As this protection wanes during the first year of life, children either receive the first dose of the measles vaccine (V1) or become susceptible to infection (S). In the second year of life, children may receive the second dose of the vaccine (V2). Additional vaccination opportunities arise through national Supplementary Immunization Activities (SIAs) targeting children under 5 years, regardless of prior vaccination status.Both susceptible and vaccinated children may acquire measles infection, with different probabilities reflecting on the vaccine’s effectiveness. An infection was categorized as moderate (IM) and assumed to be managed in an outpatient setting or severe (IS) requiring inpatient care. Following infection, children may recover (R) or die (D) from measles. Age-specific all-cause mortality was also incorporated to account for deaths unrelated to measles.The dataset includes the complete Excel-based Markov model along with all parameters used in the analysis, consistent with those reported in the accompanying manuscript. Current vaccine coverage estimates were drawn from the Kenya National Vaccine Immunization Program, while target coverage scenarios were based on historical trends or explicit assumptions. Epidemiological parameters — including reporting rates, probability of infection, vaccine efficacy, and case-fatality rates — were sourced from published literature, as detailed in the manuscript. Cost estimates were compiled from multiple sources, including UNICEF reports, published delivery-cost estimates (Levin et al., 2023), Kenya Ministry of Health costing data, and a Kenya-specific cost-of-illness study for measles. Disability-adjusted life years (DALYs) were derived from Global Burden of Disease study estimates.These inputs were used to parameterize transition probabilities across health states and to construct the Markov model for each vaccination strategy. The dataset also contains the resulting outputs, including Cost-Effectiveness Analysis (CEA) planes and Cost-Effectiveness Acceptability Curves (CEACs) for the strategies compared.

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