Figure 7 from Glioblastoma Subtypes Exhibit Distinct Migration Mechanics and Immune Responses

Le résumé fourni par la source

NRAS/mesenchymal tumors are immunologically “hot” and PDGF/proneural tumors are immunologically “cold,” consistent with human GBM subtypes. A and B, Clustering analysis of immune activators and suppressors previously reported in human GBM (Doucette and colleagues; ref. 24). Similar to mesenchymal GBM, NRAS/mesenchymal tumors have elevated immune activator and suppressor expression relative to normal brain tissue and PDGF/proneural tumors. C, Expression of immune cell surface marker genes in mouse (top) and human (bottom) tumors shows elevated expression in NRAS/mesenchymal tumors and human mesenchymal GBM tumors relative to PDGF/proneural and human proneural GBM tumors. D, IHC confirms elevated immune cell infiltration in NRAS tumors and associated elevation of immune-mediated killing of tumor cells. E–H, Quantification of IHC images using a k-means clustering algorithm. Solid and dashed lines represent the mean and median values, respectively. Error bars represent the SEM. +, P < 0.05; *, P < 0.01; **, P < 0.001; ***, P < 0.0001; ****, P < 0.00001. Statistical significance was assessed using one-way ANOVA.

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