Sex differences in sleep regularity and its associations with mortality
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Le résumé fourni par la source
Abstract In characterizing sleep and circadian health, the day–to–day regularity of sleep-wake timing strongly predicts health outcomes, outperforming short sleep duration in prospective associations with mortality and new-onset disease (1, 2). It is unknown whether biological (e.g., sleep and circadian physiology) and sociocultural (e.g., exposures that affect sleep-wake timing) sex differences lead to differences in day–to–day sleep-wake regularity or modify its prospective associations with health outcomes. Here, we present findings from a UK Biobank study of 506,582 person-days of accelerometer recordings across 73,647 middle-aged adults preceding 549,009 person-years of follow-up. We compared SRI scores between males and females and evaluated whether all–cause, cardiovascular, and cancer mortality differed across SRI groups by sex. Custom contrasts were used to compare estimated marginal means across specific SRI-sex combinations. Females were overrepresented among very high (SRI ≥90) and underrepresented among very low (SRI <60) groups. After adjustment for demographic, health, and behavioral covariates, males still had higher odds than females of exhibiting SRI <60. Low SRI and male sex were synergistically associated with higher mortality rate. Demographic, health, and behavioral covariate-adjusted models showed stronger and more dose–dependent associations between low SRI and mortality among males than females. Although the omnibus SRI × sex interaction terms were not statistically significant, the interaction contrast for SRI <60 versus ≥90 differed by sex, suggesting a possible sex difference in mortality rates at very low SRI. Together, our findings suggest that males may be more vulnerable than females to the mortality risk associated with highly irregular sleep-wake schedules.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Sex differences in sleep regularity and its associations with mortality
- Date Crossref
- 10/08/2026
- Éditeur
- openRxiv
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Brigham and Women's Hospital Department of Medicine pays non établi dans la noticeÉtablissement de santé
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Harvard University pays non établi dans la noticeUniversité ou école supérieure
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Monash University pays non établi dans la noticeUniversité ou école supérieure
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Computer Algorithms for Medicine pays non établi dans la noticeStructure de recherche
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Beth Israel Deaconess Medical Center Richard A and Susan F Smith Center for Outcomes Research pays non établi dans la noticeÉtablissement de santé
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Boston Scientific (United States) pays non établi dans la noticeEntreprise
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Lung Institute pays non établi dans la noticeÉtablissement de santé
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Deaconess Hospital pays non établi dans la noticeÉtablissement de santé
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Department of Medicine pays non établi dans la noticeInstitution
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School of Psychological Sciences and Turner Institute for Brain and Mental Health pays non établi dans la noticeUniversité ou école supérieure
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Inc. Department of Research pays non établi dans la noticeEntreprise
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Division of Sleep and Circadian Medicine pays non établi dans la noticeInstitution
Department of Medicine — Brigham and Women's Hospital, Harvard University et Monash University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.