Varicella–Zoster Virus Infection in Pregnancy: Maternal, Fetal, and Neonatal Implications in the Vaccination Era
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Le résumé fourni par la source
Infection by the varicella-zoster virus (VZV) during pregnancy is uncommon but clinically relevant, since it may compromise both the mother and the fetus. Although varicella is generally benign and self-limited in childhood, the physiological and immunological changes in pregnancy predispose individuals to more severe forms of the disease, with pneumonia representing the main maternal complication and a leading cause of morbidity and mortality. Vertical transmission may result in congenital varicella syndrome, the most severe fetal consequence, whose risk is greatest between the 13th and 20th weeks of gestation, or in severe neonatal varicella when maternal infection occurs in the peripartum period. This article presents a narrative review of the literature. To enhance methodological transparency and reproducibility, key principles of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) were applied to the literature search and study selection process. Searches were conducted in the PubMed/MEDLINE and SciELO databases, and 32 studies were included in the narrative synthesis. The review addresses the virology, pathophysiology, and epidemiology of VZV infection, including differences between temperate and tropical regions, as well as its clinical manifestations and maternal, fetal, and neonatal complications. Diagnosis is predominantly clinical, with the polymerase chain reaction being the most sensitive and specific confirmatory method and serology being useful mainly for the assessment of maternal immunity. Management encompasses the assessment of susceptibility, post-exposure prophylaxis according to current guideline recommendations, and early antiviral treatment of established infection. Preconception and postpartum vaccination remain the main preventive strategies. Despite recent advances, important gaps persist regarding prophylactic strategies and the long-term safety of antivirals during pregnancy.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Varicella–Zoster Virus Infection in Pregnancy: Maternal, Fetal, and Neonatal Implications in the Vaccination Era
- Date Crossref
- 08/08/2026
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Universidade Municipal de São Caetano do Sul pays non établi dans la noticeUniversité ou école supérieure
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Universidade de Santo Amaro pays non établi dans la noticeUniversité ou école supérieure
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Hospital Israelita Albert Einstein pays non établi dans la noticeOrganisme public
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Universidade Federal de Uberlândia pays non établi dans la noticeUniversité ou école supérieure
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Universidade Federal de São Paulo pays non établi dans la noticeUniversité ou école supérieure
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Universidade Federal do Rio de Janeiro pays non établi dans la noticeUniversité ou école supérieure
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University of Vassouras Postgraduate Program in Applied Health Sciences pays non établi dans la noticeUniversité ou école supérieure
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Universidade Federal do Estado do Rio de Janeiro pays non établi dans la noticeUniversité ou école supérieure
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Municipal University of São Caetano do Sul (USCS) Discipline of Woman Health pays non établi dans la noticeUniversité ou école supérieure
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Santo Amaro University (UNISA) Discipline of Gynecology and Obstetrics pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Federal University of Uberlândia (UFU) Department of Obstetrics and Gynecology pays non établi dans la noticeUniversité ou école supérieure
Universidade Municipal de São Caetano do Sul, Universidade de Santo Amaro et Hospital Israelita Albert Einstein, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.