Health-related quality of life after risk-reducing hysterectomy: a randomised vignette study
Rattachement africain : gb, ca. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Risk-reducing hysterectomy (RRH) is the most effective endometrial cancer preventive strategy. Understanding health-related quality-of-life using health-related utility-scores (HRUS) is essential for counselling, shared decision-making, and informing health-economic evaluations of endometrial cancer prevention. This study aimed to determine HRUS for premenopausal RRH, with and without bilateral salpingo-oophorectomy (BSO). METHODS: Preventing Endometrial-Cancers: Comparing Risk-Reducing Strategies (PRESCORES) (ISRCTN17432105) part-2 is a UK-based randomised vignette study. Following a robust development process, vignettes described four postoperative health-states for a 40-year-old otherwise-healthy woman: "RRH at 1-month", "RRH at 1-year", "RRH-BSO at 1-month", "RRH-BSO at 1-year". These were valued using EQ-5D by participants recruited from the UK general-population and HRUS calculated. Utilities were subsequently adjusted by age-and sex-matched general-population reference values. Association of variables was explored with ordinary-least-squares regression with non-parametric bootstrapping. FINDINGS: Overall, 1001 women were included and randomised to 1-of-4 groups. The mean-age(±SD) was 53.6 (±11.4) years. Mean(±SD) HRUS were 0.942 (±0.072) for "RRH at 1-year", 0.841 (±0.137) for "RRH-BSO at 1-year", 0.670 (±0.149) for "RRH at 1-month", and 0.733 (±0.190) for "RRH-BSO at 1-month", with significant difference between each group (p < 0.001). Adjusting for age-sex-matched population reference utilities, HRUS were 1.000(95% CI:1.00-1.00), 0.994(95% CI:0.97-1.00), 0.866(95% CI:0.84-0.90) and 0.791(95% CI:0.77-0.81), respectively. Participant factors associated with vignette valuations included age, obesity, heavy menstrual-bleeding, higher income and mixed/other ethnicity. CONCLUSION: This randomised study provides HRUS following premenopausal RRH with and without BSO at two postoperative time-points, with adjustment against the age-and sex-matched general reference-population. These values are of relevance for informing counselling of women at increased endometrial cancer-risk regarding RRH and for health-economic evaluations.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Health-related quality of life after risk-reducing hysterectomy: a randomised vignette study
- Date Crossref
- 01/09/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Queen Mary University of London Wolfson Institute of Population Health pays non établi dans la noticeUniversité ou école supérieure
-
Barts Health NHS Trust pays non établi dans la noticeÉtablissement de santé
-
University of London pays non établi dans la noticeUniversité ou école supérieure
-
London School of Hygiene & Tropical Medicine Department of Health Services Research and Policy pays non établi dans la noticeUniversité ou école supérieure
-
Royal London Hospital Department of Gynaecological Oncology pays non établi dans la noticeÉtablissement de santé
-
St Mary's Hospital pays non établi dans la noticeÉtablissement de santé
-
University of British Columbia pays non établi dans la noticeUniversité ou école supérieure
-
Imperial College Healthcare NHS Trust pays non établi dans la noticeÉtablissement de santé
-
London North West Healthcare NHS Trust pays non établi dans la noticeÉtablissement de santé
-
Synome (United Kingdom) pays non établi dans la noticeEntreprise
-
University of Manchester Infection and Genomic Sciences pays non établi dans la noticeUniversité ou école supérieure
-
London North West University Healthcare NHS Trust St Mark's Hospital pays non établi dans la noticeUniversité ou école supérieure
Wolfson Institute of Population Health — Queen Mary University of London, Barts Health NHS Trust et University of London, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.