Asymptomatic kidney changes discovered during occupational health screening: age-dependent trends from a large cohort
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Le résumé fourni par la source
Background: The urinary albumin-to-creatinine ratio (uACR) and estimated glomerular filtration rate (eGFR) are key biomarkers for asymptomatic detection of chronic kidney disease (CKD), yet their combined use in preventive screening-particularly among young adults-remains uncommon. This study evaluates CKD markers in a large occupational cohort, emphasizing the early renal alterations observed in the 19-30-year age group and their distribution across older age strata. Methods: Between 2021 and 2024, 12 281 healthcare workers aged 19-71 years participated in an occupational health surveillance program at the University Hospital of Bari, Italy. CKD was evaluated using eGFR ( Chronic Kidney disease Epidemiology Collaboration ;CKD-EPI) and uACR from spot urine samples, with classification based on the KDIGO (Kidney Disease: Improving Global Outcomes) guidelines (2024). The results were stratified by age (19-30, 31-60, and >60 years) and comorbidities. Results: = 2907): Only 84% remained in the lowest KDIGO prognostic category (G1-G2/A1), whereas 16% exhibited elevated uACR and/or reduced eGFR, consistent with age-related renal decline and a higher comorbidity burden.Among the 74 individuals with severe albuminuria (A3), 10 underwent renal biopsy, which revealed IgA nephropathy, nephroangiosclerosis, lupus nephritis, and membranous glomerulonephritis (GN. Conclusion: Even in a predominantly healthy working population, one in 20 young adults demonstrated asymptomatic kidney alterations identifiable only through uACR screening. These findings underscore the importance of integrating both uACR and eGFR testing into occupational and preventive health programs to detect mild CKD in all age groups and promote kidney health preservation from early adulthood.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Asymptomatic kidney changes discovered during occupational health screening: age-dependent trends from a large cohort
- Date Crossref
- 31/07/2026
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Foggia Department of Medical and Surgical Sciences pays non établi dans la noticeUniversité ou école supérieure
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University of Bari Aldo Moro Department of Precision and Regenerative Medicine and Ionian Area (DIMEPRE-J) pays non établi dans la noticeUniversité ou école supérieure
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Department of Medical Sciences pays non établi dans la noticeStructure de recherche
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Università Cattolica del Sacro Cuore pays non établi dans la noticeUniversité ou école supérieure
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Ministero della Salute pays non établi dans la noticeOrganisme public
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University of Campania "Luigi Vanvitelli" pays non établi dans la noticeUniversité ou école supérieure
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University Hospital of Bari Clinical Pathology Unit pays non établi dans la noticeUniversité ou école supérieure
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University Hospital City of Health and Science of Turin pays non établi dans la noticeUniversité ou école supérieure
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Department of Translational Medicine and Surgery pays non établi dans la noticeInstitution
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Ministry of Health Directorate-General for Communication pays non établi dans la noticeOrganisme public
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University “Luigi Vanvitelli” of Naples Nephrology Division pays non établi dans la noticeUniversité ou école supérieure
Department of Medical and Surgical Sciences — University of Foggia, Department of Precision and Regenerative Medicine and Ionian Area (DIMEPRE-J) — University of Bari Aldo Moro et Department of Medical Sciences, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.