Additional file 1 of Assessment of Trophoblast cell surface antigen 2 (Trop-2) expression and its clinical significance in breast cancer: a multi-level analysis of protein and gene expression

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Additional file 1 Supplementary methods, Tables S1-S6, and Figures S1-S8. Supplementary methods-Search strategy of Trop-2 protein expression; Description of the QuPath workflow. Table S1-Full search strategies for all databases. Table S2-Characteristics of studies included in the pooled IHC Trop-2 analysis and meta-analysis. Table S3-Patient characteristics by Trop-2 protein expression (QuPath H-score). Table S4-Patient characteristics by Trop-2 gene expression. Table S5-Univariable and multivariable Cox regression analyses of Trop-2 protein expression. Table S6-Univariable and multivariable Cox regression analyses of Trop-2 gene expression. Figure S1-Flow diagram of patient selection for the cohort study. Figure S2-Controls used for immunohistochemistry staining (IHC). Figure S3-PRISMA flowchart. Figure S4-Forest plots for OS by Trop-2 expression: Trop-2–directed ADCs vs chemotherapy. Figure S5-Boxplot of QuPath-generated H-score by observer-read Trop-2 protein expression groups. Figure S6-Boxplots of Trop-2 gene expression by protein expression groups. Figure S7-Kaplan–Meier curves for DRFI by Trop-2 protein expression (QuPath H-score). Figure S8-Kaplan–Meier curves for OS by Trop-2 protein expression (observer-read score and QuPath H-score)

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.