Does cognitive performance decline as a function of age at onset in Parkinson’s disease? the role of age at assessment, education, and clinical severity
Rattachement africain : mx, pe, au. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Parkinson’s disease (PD) may present with early-onset (EOPD) or late-onset (LOPD). Lower cognitive performance has been reported more frequently in LOPD, although findings remain inconsistent, partly due to limited control of confounders such as age at assessment, education, and disease severity. To evaluate associations of age at assessment, age at onset, education, clinical severity, and emotional factors with cognitive performance in PD, and to compare performance between EOPD, LOPD, and controls in Mexico. We analyzed 249 patients with PD and 102 healthy controls from the Mex-PD cohort. Cognition was assessed using the Montreal Cognitive Assessment (MoCA). Multiple linear regression models identified variables associated with cognitive performance. Given collinearity among age-related variables, moderation analyses examined interactions between age at assessment, age at onset, group, and disease severity. Nearest-neighbor matching was used for group comparisons. Age at assessment was most strongly associated with lower cognitive performance, followed by education and disease severity. Age at onset was not independently associated with cognition. Cognitive differences between EOPD and LOPD disappeared after controlling for age at assessment. Disease severity was significantly associated with lower cognitive performance from 59 years onward. In matched samples, both PD groups showed lower global cognition than controls, with delayed recall most affected. In this cross-sectional study, lower cognitive performance in PD was more strongly associated with age at assessment and its interaction with disease severity than with age at onset. Education and cognitive reserve were positively associated with cognitive performance, consistent with their protective role.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Does cognitive performance decline as a function of age at onset in Parkinson’s disease? the role of age at assessment, education, and clinical severity
- Date Crossref
- 04/08/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Universidad Nacional Autónoma de México pays non établi dans la noticeUniversité ou école supérieure
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Autonomous University of Queretaro pays non établi dans la noticeUniversité ou école supérieure
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Prisma pays non établi dans la noticeOrganisation à but non lucratif
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Institute for Social Security and Services for State Workers pays non établi dans la noticeOrganisme public
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Universidad Autónoma de Nuevo León pays non établi dans la noticeUniversité ou école supérieure
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Hospital General de México pays non établi dans la noticeÉtablissement de santé
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Centro Médico ABC pays non établi dans la noticeÉtablissement de santé
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The University of Queensland pays non établi dans la noticeUniversité ou école supérieure
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QIMR Berghofer Medical Research Institute Brain & Mental Health Program pays non établi dans la noticeStructure de recherche
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Laboratorio de Neurogenómica Cognitiva pays non établi dans la noticeInstitution
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Laboratorio Internacional de Investigación sobre el Genoma Humano pays non établi dans la noticeInstitution
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Instituto de Neurobiología pays non établi dans la noticeStructure de recherche
Universidad Nacional Autónoma de México, Autonomous University of Queretaro et Prisma, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.