Additive Manufacturing of Biomaterials: Integrated Translational Ecosystems, Process–Structure–Property Interactions and Emerging Paradigms for Next-Generation Biomedical Engineering
Rattachement africain : pt, cn. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Additive manufacturing (AM) has expanded the design space of biomaterials for biomedical engineering, enabling patient-specific geometries, controlled porosity, multi-material constructs and cell-compatible fabrication. However, clinical translation remains constrained by a mismatch between fabrication capability and biological, mechanical and regulatory performance. Unlike reviews focused on individual material families, isolated AM routes or specific applications, this review interprets AM of biomaterials as an integrated biomaterial-process-structure-property-translation ecosystem. It examines how material chemistry, feedstock state, printing route, architecture, post-processing and biological response jointly determine the reliability of acellular and cellular constructs, with particular emphasis on clinically relevant performance, reproducibility and long-term safety. Metallic, ceramic, polymeric, hydrogel-based and composite biomaterials are analysed alongside binder jetting (BJ), directed energy deposition (DED), material extrusion (ME) and jetting (MJ), powder bed fusion (PBF), VAT photopolymerisation and bioprinting. The review identifies recurring challenges across routes, including restricted material-process compatibility, limited prediction of process-structure-property relationships, post-processing-induced changes in biological performance, insufficient standardisation of printability and biofunctionality metrics, incomplete validation of cell-laden and vascularised constructs and weak transfer of laboratory protocols to clinically robust workflows. The main conclusion is that progress will depend less on expanding printable geometries alone and more on integrated optimisation of materials, processing windows, structural fidelity, biological validation, quality assurance and translational readiness. This ecosystem-level perspective provides a framework for evaluating limitations and defining future priorities in AM-based biomaterials for regenerative medicine, implants and precision biomedical engineering.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Additive Manufacturing of Biomaterials: Integrated Translational Ecosystems, Process–Structure–Property Interactions and Emerging Paradigms for Next-Generation Biomedical Engineering
- Date Crossref
- 30/07/2026
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Universidade do Porto pays non établi dans la noticeUniversité ou école supérieure
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Centro de Investigação e Desenvolvimento em Engenharia Mecânica pays non établi dans la noticeStructure de recherche
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Polytechnic Institute of Porto pays non établi dans la noticeUniversité ou école supérieure
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Nanjing University of Aeronautics and Astronautics pays non établi dans la noticeUniversité ou école supérieure
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Institute of Mechanical Engineering and Industrial Mangement pays non établi dans la noticeStructure de recherche
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Polytechnic of Porto ISEP pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Engineering Department of Mechanical Engineering pays non établi dans la noticeUniversité ou école supérieure
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College of Mechanical and Electrical Engineering pays non établi dans la noticeUniversité ou école supérieure
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Associate Laboratory for Energy pays non établi dans la noticeStructure de recherche
Universidade do Porto, Centro de Investigação e Desenvolvimento em Engenharia Mecânica et Polytechnic Institute of Porto, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.