Menopausal status modifies the association between migraine and cardiovascular disease risk: a nationwide cohort study
Rattachement africain : kr. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
To evaluate whether menopausal status modifies the association between migraine and cardiovascular disease (CVD) risk in women, using both relative and absolute risk measures. We conducted a nationwide cohort study using Korean National Health Insurance Service data. Women aged ≥ 40 years who underwent the 2009 health screening and had no prior CVD (myocardial infarction or stroke) were included. Migraine was defined by using ICD-10 diagnostic codes. Menopausal status was determined from questionnaire-based reproductive history and prespecified as an effect modifier. Incident CVD and cardiovascular death were ascertained. Multivariable Cox models were used to estimate hazard ratios (HRs). Among 2,156,733 women, 923,517 were premenopausal and 1,233,216 postmenopausal. In premenopausal women, CVD incidence was higher in those with migraine than in those without migraine (2.22 vs. 1.38 per 1,000 person-years), with a higher risk after multivariable adjustment (HR 1.53, 95% CI 1.42–1.66). In postmenopausal women, CVD incidence was also higher among those with migraine (9.53 vs. 7.50 per 1,000 person-years), although the relative association was attenuated but remained significant (HR 1.20, 95% CI 1.17–1.23). Accordingly, the crude incidence rate difference associated with migraine was larger after menopause (2.03 vs. 0.84 per 1,000 person-years). The relative associations between migraine and cardiovascular outcomes were stronger in premenopausal women, whereas larger absolute risk differences were observed in postmenopausal women. This pattern was observed for CVD, myocardial infarction, and ischemic stroke, but not for cardiovascular death. Migraine was associated with increased CVD risk in women. Relative associations were stronger before menopause, whereas absolute excess incidence was greater after menopause. These findings highlight the importance of considering migraine in cardiovascular risk assessment across the female life course, including after menopause.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Menopausal status modifies the association between migraine and cardiovascular disease risk: a nationwide cohort study
- Date Crossref
- 29/07/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Seoul National University Bundang Hospital Department of Neurology and Cerebrovascular Center pays non établi dans la noticeÉtablissement de santé
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Soongsil University Department of Statistics and Actuarial Science pays non établi dans la noticeUniversité ou école supérieure
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Soonchunhyang University Hospital Seoul pays non établi dans la noticeÉtablissement de santé
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Hallym University Dongtan Sacred Heart Hospital Department of Internal Medicine pays non établi dans la noticeÉtablissement de santé
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Hallym University Sacred Heart Hospital Department of Neurology pays non établi dans la noticeÉtablissement de santé
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Seoul National University Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Soonchunhyang University Seoul Hospital Department of Neurology pays non établi dans la noticeUniversité ou école supérieure
Department of Neurology and Cerebrovascular Center — Seoul National University Bundang Hospital, Department of Statistics and Actuarial Science — Soongsil University et Soonchunhyang University Hospital Seoul, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.