Predictive Biomarker of Hepatitis B and C Infection among Thalassemia Patients in Faisalabad, Punjab, Pakistan
Rattachement africain : pk. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: Transfusion-dependent β-thalassemia patients are particularly susceptible to transfusion-transmitted infections, especially hepatitis B virus (HBV) and hepatitis C virus (HCV), owing to lifelong dependence on repeated blood transfusions. Chronic viral hepatitis, together with transfusion-related iron overload, contributes substantially to progressive liver injury and adverse hematological outcomes. This study investigated the association between HBV and HCV infections and biochemical as well as hematological parameters in transfusion-dependent β-thalassemia patients and identified significant predictors of hepatic involvement. Methods: A cross-sectional analytical study was conducted among transfusion-dependent β-thalassemia patients attending a specialized thalassemia care center in Faisalabad, Punjab, Pakistan. Participants were categorized into four groups: non-infected, HBV-infected, HCV-infected, and HBV/HCV co-infected. Demographic characteristics, clinical history, biochemical markers including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and serum bilirubin, together with hematological indices, were recorded. Statistical analyses were performed using SPSS version 26. Descriptive statistics, correlation analysis, chi-square tests, independent-samples t-tests, and logistic regression analyses were employed to identify significant predictors of hepatitis infection. Results: Hepatitis infection was significantly associated with an increased number of blood transfusions. Patients with HBV, HCV, and particularly HBV/HCV co-infection demonstrated significantly elevated AST, ALT, and serum bilirubin concentrations compared with non-infected patients (p < 0.01). Positive correlations were observed between transfusion frequency and liver enzyme levels. Significant alterations were also identified in hematological indices, including mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and red cell distribution width (RDW), whereas total white blood cell counts showed no statistically significant differences. Logistic regression analysis identified the cumulative number of transfusions, AST, ALT, serum bilirubin, and hepatitis infection status as independent predictors of hepatic involvement, with HCV exhibiting the strongest association. Conclusions: Transfusion-dependent β-thalassemia patients remain at substantial risk of HBV and HCV infections despite advances in blood safety practices. Viral hepatitis significantly impairs liver function and alters hematological profiles, emphasizing the importance of rigorous donor screening, regular biochemical monitoring, timely antiviral management, and strengthened infection prevention strategies to reduce disease burden and improve long-term clinical outcomes.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Predictive Biomarker of Hepatitis B and C Infection among Thalassemia Patients in Faisalabad, Punjab, Pakistan
- Date Crossref
- 30/06/2026
- Éditeur
- Wah Academia (SMC-PVT) Ltd
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Punjab Medical College pays non établi dans la noticeUniversité ou école supérieure
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University of Faisalabad pays non établi dans la noticeUniversité ou école supérieure
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University of Agriculture Faisalabad pays non établi dans la noticeUniversité ou école supérieure
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Government College University Institute of Microbiology pays non établi dans la noticeUniversité ou école supérieure
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University of Haripur pays non établi dans la noticeUniversité ou école supérieure
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Riphah International University Department of Medical Lab Technology pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine and Allied Health Sciences Department of Medical Lab Sciences pays non établi dans la noticeUniversité ou école supérieure
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Faisalabad Medical University Faisalabad Department of Pathology pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Sciences Department of Biochemistry pays non établi dans la noticeUniversité ou école supérieure
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College of Allied Health Professionals pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Allied Health Professionals Department of Medical Lab Technology pays non établi dans la noticeUniversité ou école supérieure
Punjab Medical College, University of Faisalabad et University of Agriculture Faisalabad, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.