Novel Phosphatase SSU72 Drives Malignant Progression in Colorectal Cancer via PERK Thr982 Dephosphorylation Mediated Endoplasmic Reticulum Stress Inactivation

Le résumé fourni par la source

experimental validation confirmed that SSU72-mediated suppression of endoplasmic reticulum stress promoted tumor aggressiveness. Clinically, SSU72 serves as a novel biomarker for colorectal cancer poor prognosis, and targeting its phosphatase activity to restore endoplasmic reticulum stress represents a therapeutic strategy for SSU72-high tumors. This study uncovers SSU72's dual role: beyond its canonical functions in transcription and cell cycle regulation, it directly modulates endoplasmic reticulum stress to promote colorectal cancer malignancy. Our findings address critical deficiencies in understanding colorectal cancer heterogeneity and propose SSU72 as a prognostic biomarker and viable target for precision therapy.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.