Abstract Wed132: Global Peripheral Artery Disease Burden Attributable to Metabolic Risks, 1990–2023: Trends Across Demographics and Development Levels
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Le résumé fourni par la source
Background: Peripheral artery disease (PAD) constitutes a major component of global atherosclerotic burden, with metabolic risk factors playing a pivotal role in disease onset and progression. However, the long-term population-level impact of metabolic risks on PAD and its stratification by region, age, and sex remain poorly characterized. Methods: Using the GBD 2023 framework, we quantified the 1990–2023 metabolic risk-attributable PAD burden across 204 countries. Population attributable fractions (PAFs) were calculated from exposure distributions, relative risks, and theoretical minimum exposure levels. Trends in counts and age-standardized rates—stratified by age, sex, and location—were analyzed using log-linear models to determine average annual percent change (AAPC). Results: From 1990-2023, the global PAD burden attributable to metabolic risks increased substantially, with absolute deaths rising from 21,468.5 to 43,236.4(AAPC 2.00%), DALYs rising from 482,156.9 to 1,027,905.4(AAPC 2.21%), and YLDs rising from 143,142.9 to 381,593.1(AAPC 3.12%). Among individual metabolic risks, high fasting plasma glucose and high body-mass index experienced the most rapid growth, with AAPC for DALYs of 2.92% and 2.64%, respectively, followed by kidney dysfunction (2.15%) and high systolic blood pressure (1.64%). Despite rising absolute counts, the global age-standardized rates improved over time, with annual declines in mortality ( −1.37%) and DALYs (−0.84%), while disability rates (YLDs) remained nearly stagnant(+0.12%). Regional trends followed an SDI gradient: DALYs rates improved in High-SDI countries (−1.22%), stabilized in High-middle SDI (−0.03%), and worsened in Middle, Low-middle, and Low-SDI regions (+0.70% to +1.41%). Age-specific analyses revealed a growing burden in younger populations: in those under 70, metabolic-related rates increased (Deaths/YLLs/YLDs: +0.28%/+0.28%/+1.57%), while the 70+ group saw declining mortality (−0.80% to −1.00%) and stable disability (+0.30%). Sex-specific analysis showed that from 1990-2023, death rate (−1.35% in males vs −1.46% in females) and YLL rates (−1.31% vs. −1.36%) declined for both sexes, while YLD rose more in females (+0.22%) than males (+0.02%). Conclusion: Global PAD burden attributable to metabolic risks doubled since 1990, driven by hyperglycemia and obesity. Rising burdens among younger individuals and lower-SDI regions reveal emerging inequities, warranting urgent targeted metabolic risk prevention strategies.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Abstract Wed132: Global Peripheral Artery Disease Burden Attributable to Metabolic Risks, 1990–2023: Trends Across Demographics and Development Levels
- Date Crossref
- 01/05/2026
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
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Manor College pays non établi dans la noticeUniversité ou école supérieure
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Manor College, HCR Manor Care et Springfield Clinic, avec 9 autres affiliations.
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