Radiation-induced green fabrication of sodium hyaluronate-functionalized selenium nanohybrids for improved camptothecin delivery and anticancer efficacy
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Le résumé fourni par la source
A rapid and efficient gamma radiation-driven method was developed to fabricate sodium hyaluronate-functionalized selenium nanohybrids (SeNHs@HA) for targeted delivery of camptothecin (CPT), aiming to improve selectivity, therapeutic efficacy, and safety. Sodium hyaluronate (HA) was employed as a stabilizing, capping and surface functionalizing agent for SeNPs, leading to the formation of SeNHs@HA. Key parameters, including pH, HA concentration and gamma irradiation dose, were systematically optimized to precisely control particle size, morphology, and surface characteristics. Under optimized conditions, core-shell structured SeNHs@HA were successfully synthesized via a green approach and exhibited a uniform, monodispersed spherical morphology with an average diameter of 64.10 nm. The hydrophobic CPT was efficiently encapsulated within the multifunctional nanocarrier, resulting in enlarged CPT-SeNHs@HA nanostructures with improved physicochemical properties, enhanced cellular uptake, and increased targeting capability. The nanohybrids demonstrated a distinct pH-responsive release behavior, with accelerated drug release under acidic conditions, reaching 74.58% at 72 h. Cytotoxicity studies demonstrated significantly enhanced anticancer activity against MCF-7 cells (IC 50 =0.79 µM), representing a 5.96-fold improvement over free CPT (IC 50 =4.71 µM). Additionally, the system induced early apoptosis (32.91%) and S-phase cell cycle arrest. These findings highlight smart CPT-SeNHs@HA as a promising platform for targeted breast cancer drug delivery system.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Radiation-induced green fabrication of sodium hyaluronate-functionalized selenium nanohybrids for improved camptothecin delivery and anticancer efficacy
- Date Crossref
- 01/09/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Thailand Institute of Nuclear Technology Nuclear Technology Research and Development Center pays non établi dans la noticeStructure de recherche
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National Nuclear Energy Agency of Indonesia pays non établi dans la noticeStructure de recherche
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Research Organization for Nuclear Energy pays non établi dans la noticeOrganisme public
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Thammasat University pays non établi dans la noticeUniversité ou école supérieure
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Chulalongkorn University pays non établi dans la noticeUniversité ou école supérieure
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Research Center for Radiation Processing Technology pays non établi dans la noticeStructure de recherche
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Faculty of Science Department of Biology pays non établi dans la noticeUniversité ou école supérieure
Nuclear Technology Research and Development Center — Thailand Institute of Nuclear Technology, National Nuclear Energy Agency of Indonesia et Research Organization for Nuclear Energy, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.