HIV-associated neurocognitive disorders, among adolescents with HIV in India
Rattachement africain : Afrique du Sud. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Research on neurocognition among Indian adolescents with HIV (AHIV) has only recently begun to emerge, with earlier studies predominantly focusing on adult cohorts or international populations. OBJECTIVE: This study examined neurocognitive functioning in adolescents aged 11-16 years from Bengaluru, Karnataka, comparing perinatally infected AHIV with healthy controls. DESIGN AND METHODS: This cross-sectional study investigated HIV-associated neurocognitive disorder (HAND) in 148 participants, 70 perinatally infected AHIV and 78 controls. Participants completed a neurocognitive battery assessing eight domains: attention, processing speed, verbal memory, visual memory, visual-spatial memory, language, motor coordination, and executive functioning. RESULTS: AHIV performed significantly worse than controls across all assessed domains, reflecting widespread and multidomain cognitive vulnerability during adolescence. Significant impairments were observed in attention (estimate = -0.83, P < 0.001), processing speed (estimate = -0.81, P < 0.001), executive functioning (estimate = -0.82, P < 0.001), language (estimate = -0.68, P < 0.001), verbal memory (estimate = -0.46, P < 0.001), motor coordination (estimate = -0.46, P < 0.001), and visual memory (estimate = -0.29, P < 0.001). The assessment battery, originally validated in South Africa, demonstrated reliability (Cronbach's α ranging from 0.67 to 0.88) and cultural sensitivity through rigorous translation and back-translation procedures, supporting its cross-cultural applicability in the Indian context. CONCLUSION: Neurocognitive impairment remains a persistent and clinically meaningful outcome of perinatal HIV infection despite antiretroviral therapy, underscoring the urgent need for standardized neurocognitive assessment and early intervention for AHIV in low- and middle-income country (LMIC) settings.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- HIV-associated neurocognitive disorders, among adolescents with HIV in India
- Date Crossref
- 23/07/2026
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Cape Town Department of Psychiatry University of Cape Town, Afrique du Sud (code pays fourni par la source)Université ou école supérieure
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University of Johannesburg University of Johannesburg, Afrique du Sud (code pays fourni par la source)Université ou école supérieure
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University of Pretoria Department of Psychology University of Pretoria, Afrique du Sud (code pays fourni par la source)Université ou école supérieure
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Department of Psychology pays non établi dans la noticeInstitution
Department of Psychiatry — University of Cape Town (University of Cape Town, Afrique du Sud), University of Johannesburg (University of Johannesburg, Afrique du Sud) et Department of Psychology — University of Pretoria (University of Pretoria, Afrique du Sud), avec 1 autre affiliation. Pays d’affiliation : Afrique du Sud.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.